Measurement of Interleukin-33 (IL-33) and IL-33 Receptors (sST2 and ST2L) in Patients with Rheumatoid Arthritis
DC Field | Value | Language |
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dc.contributor.author | Hong, Yeon-Sik | - |
dc.contributor.author | Moon, Su-Jin | - |
dc.contributor.author | Joo, Young-Bin | - |
dc.contributor.author | Jeon, Chan-Hong | - |
dc.contributor.author | Cho, Mi-La | - |
dc.contributor.author | Ju, Ji Hyeon | - |
dc.contributor.author | Oh, Hye-Jwa | - |
dc.contributor.author | Heo, Yu-Jung | - |
dc.contributor.author | Park, Sung-Hwan | - |
dc.contributor.author | Kim, Ho-Youn | - |
dc.contributor.author | Min, Jun-Ki | - |
dc.date.accessioned | 2021-08-12T05:24:37Z | - |
dc.date.available | 2021-08-12T05:24:37Z | - |
dc.date.issued | 2011-09 | - |
dc.identifier.issn | 1011-8934 | - |
dc.identifier.issn | 1598-6357 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/16269 | - |
dc.description.abstract | The interleukin-33 (IL-33)/ST2 pathway has emerged as an intercellular signaling system that participates in antigen-allergen response, autoimmunity and fibrosis. It has been suggested that IL-33/ST2 signaling has been involved in the pathogenesis of rheumatoid arthritis (RA), because IL-33 and its receptor have been specifically mapped to RA synovium. The aim of this study was to determine the levels of IL-33 and sST2 in sera and synovial fluids in patients with RA. The serum level of IL-33 was significantly higher in patients with RA (294.9 +/- 464.0 pg/mL) than in healthy controls (96.0 +/- 236.9 pg/mL, P = 0.002). The synovial fluid level of IL-33 was significantly higher in RA patients than in osteoarthritis patients. The level of serum sST2 was higher in RA patients than in healthy controls (P = 0.042). A significant relationship was found between the levels of IL-33 and IL-1 beta (r= 0.311, P = 0.005), and IL-33 and IL-6 (r= 0.264, P= 0.017) in 81 RA patients. The levels of IL-33, sST2 and C-reactive protein decreased after conventional disease-modifying antirheumatic drugs treatment in 10 patients with treatment-naive RA. Conclusively, IL-33 is involved in the pathogenesis of RA and may reflect the degree of inflammation in patients with RA. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 대한의학회 | - |
dc.title | Measurement of Interleukin-33 (IL-33) and IL-33 Receptors (sST2 and ST2L) in Patients with Rheumatoid Arthritis | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.3346/jkms.2011.26.9.1132 | - |
dc.identifier.scopusid | 2-s2.0-80052818476 | - |
dc.identifier.wosid | 000295191500003 | - |
dc.identifier.bibliographicCitation | Journal of Korean Medical Science, v.26, no.9, pp 1132 - 1139 | - |
dc.citation.title | Journal of Korean Medical Science | - |
dc.citation.volume | 26 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 1132 | - |
dc.citation.endPage | 1139 | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001586190 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | CYTOKINE IL-33 | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordAuthor | Interleukin-33 | - |
dc.subject.keywordAuthor | sST2 | - |
dc.subject.keywordAuthor | ST2L | - |
dc.subject.keywordAuthor | Arthritis | - |
dc.subject.keywordAuthor | Rheumatoid | - |
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