Suppression of the TRIF-dependent signaling pathway of toll-like receptors by (E)-isopropyl 4-oxo-4-(2-oxopyrrolidin-1-yl)-2-butenoate
DC Field | Value | Language |
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dc.contributor.author | Park, Se-Jeong | - |
dc.contributor.author | Park, Hye-Jeong | - |
dc.contributor.author | Kim, Soo-Jung | - |
dc.contributor.author | Shin, Hwa-Jeong | - |
dc.contributor.author | Min, In Soon | - |
dc.contributor.author | Koh, Kwang Oh | - |
dc.contributor.author | Kim, Dae Young | - |
dc.contributor.author | Youn, Hyung-Sun | - |
dc.date.accessioned | 2021-08-12T05:25:37Z | - |
dc.date.available | 2021-08-12T05:25:37Z | - |
dc.date.issued | 2011-07-31 | - |
dc.identifier.issn | 1976-6696 | - |
dc.identifier.issn | 1976-670X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/16335 | - |
dc.description.abstract | Toll-like receptors (TLRs) are pattern recognition receptors that recognize molecular structures derived from microbes and initiate innate immunity. TLRs have two downstream signaling pathways, the MyD88- and TRIF-dependent pathways. Dysregulated activation of TLRs is closely linked to increased risk of many chronic diseases. Previously, we synthesized fumaryl pyrrolidinone, (E)-isopropyl 4-oxo-4-(2-oxopyrrolidin-1-yl)-2-butenoate (IPOP), which contains a fumaric acid isopropyl ester and pyrrolidinone, and demonstrated that it inhibits the activation of nuclear factor kappa B by inhibiting the MyD88-dependent pathway of TLRs. However, the effect of IPOP on the TRIF-dependent pathway remains unknown. Here, we report the effect of IPOP on signal transduction via the TRIF-dependent pathway of TLRs. IPOP inhibited lipopolysaccharide- or polyinosinic-polycytidylic acid-induced interferon regulatory factor 3 activation, as well as interferon-inducible genes such as interferon inducible protein-10. These results suggest that IPOP can modulate the TRIF-dependent signaling pathway of TLRs, leading to decreased inflammatory gene expression. [BMB reports 2011; 44(7): 468-472] | - |
dc.format.extent | 5 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 생화학분자생물학회 | - |
dc.title | Suppression of the TRIF-dependent signaling pathway of toll-like receptors by (E)-isopropyl 4-oxo-4-(2-oxopyrrolidin-1-yl)-2-butenoate | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.5483/BMBRep.2011.44.7.468 | - |
dc.identifier.scopusid | 2-s2.0-79961036230 | - |
dc.identifier.wosid | 000293358300007 | - |
dc.identifier.bibliographicCitation | BMB Reports, v.44, no.7, pp 468 - 472 | - |
dc.citation.title | BMB Reports | - |
dc.citation.volume | 44 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 468 | - |
dc.citation.endPage | 472 | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001572945 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.subject.keywordPlus | CYCLOOXYGENASE-2 EXPRESSION | - |
dc.subject.keywordPlus | INNATE IMMUNITY | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | ALPHA | - |
dc.subject.keywordPlus | HOMODIMERIZATION | - |
dc.subject.keywordPlus | RECOGNITION | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordAuthor | Fumaryl pyrrolidinone | - |
dc.subject.keywordAuthor | Lipopolysaccharide | - |
dc.subject.keywordAuthor | Polyinosinic-polycytidylic acid | - |
dc.subject.keywordAuthor | Toll-like receptor | - |
dc.subject.keywordAuthor | TRIF | - |
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