Is the addition of choleretic agents in multiple double-pigtail biliary stents effective for difficult common bile duct stones in elderly patients? A prospective, multicenter study
DC Field | Value | Language |
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dc.contributor.author | Lee, Tae Hoon | - |
dc.contributor.author | Han, Joung-Ho | - |
dc.contributor.author | Kim, Hong Ja | - |
dc.contributor.author | Park, Seon Mee | - |
dc.contributor.author | Park, Sang-Heum | - |
dc.contributor.author | Kim, Sun-Joo | - |
dc.date.accessioned | 2021-08-12T05:26:02Z | - |
dc.date.available | 2021-08-12T05:26:02Z | - |
dc.date.issued | 2011-07 | - |
dc.identifier.issn | 0016-5107 | - |
dc.identifier.issn | 1097-6779 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/16368 | - |
dc.description.abstract | Background: Temporary biliary stenting is both technically easy and feasible, and choleretic agents such as ursodeoxycholic acid (UDCA) and a terpene preparation may promote a reduction in stone size. However, there are few comparative data on the effectiveness of choleretic agents available. Objective: To investigate the efficacy of multiple double-pigtail stents with or without UDCA and terpene on difficult common bile duct (CBD) stones. Design: A prospective, multicenter study. Setting: Four tertiary-care referral centers. Patients: This study involved 51 patients. Intervention: In total, 51 elderly patients with comorbidities who had difficult CBD stones refractory to conventional methods were randomized to receive either multiple 7F double-pigtail stents (group A) or stents in combination with UDCA and terpene (group B) for a period of 6 months. Main Outcome Measurements: Stone size reduction, successful duct clearance, and complications. Results: Complete endoscopic duct clearance was achieved in 14 patients (73.7%) in group A and 19 patients (86.4%) in group B (P = .826). The mean size of CBD stones (transverse/longitudinal diameter, mean +/- SD) was 19.12 +/- 4.48 mm/20.47 +/- 3.86 mm in group A and 21.30 +/- 7.08 mm/22.58 +/- 7.61 mm in group B. Stone size decreased significantly to 12.04 +/- 3.26 mm/13.31 +/- 5.12 mm and 13.67 +/- 5.40 mm/14.04 +/- 6.12 mm, respectively (P < .01). However, there was no statistical difference in stone size reduction between the two groups (P = .685, P = .289). No serious complications related to the stent or endoscopic procedures were observed, except for cholangitis (n = 1, group A) and distal stem migration (n = 2, group B). Limitations: Small number of patients in East Asia. Conclusion: Temporary multiple double-pigtail biliary stenting was a safe and feasible method of treating difficult and large CBD stones in elderly patients and contributed to a reduction in stone size and successful duct clearance. However, the addition of choleretic agents did not result in a statistical difference in stone size or rate of successful duct clearance. (Gastrointest Enclose 201174:96-102.) | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Mosby Inc. | - |
dc.title | Is the addition of choleretic agents in multiple double-pigtail biliary stents effective for difficult common bile duct stones in elderly patients? A prospective, multicenter study | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1016/j.gie.2011.03.005 | - |
dc.identifier.wosid | 000292429400013 | - |
dc.identifier.bibliographicCitation | Gastrointestinal Endoscopy, v.74, no.1, pp 96 - 102 | - |
dc.citation.title | Gastrointestinal Endoscopy | - |
dc.citation.volume | 74 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 96 | - |
dc.citation.endPage | 102 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.subject.keywordPlus | LONG-TERM TREATMENT | - |
dc.subject.keywordPlus | URSODEOXYCHOLIC ACID | - |
dc.subject.keywordPlus | ENDOSCOPIC SPHINCTEROTOMY | - |
dc.subject.keywordPlus | LIPID SECRETION | - |
dc.subject.keywordPlus | MANAGEMENT | - |
dc.subject.keywordPlus | ENDOPROSTHESES | - |
dc.subject.keywordPlus | COMBINATION | - |
dc.subject.keywordPlus | ROWACHOL | - |
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