The Neurobiological Role of the Dorsolateral Prefrontal Cortex in Recovery From Trauma Longitudinal Brain Imaging Study Among Survivors of the South Korean Subway Disaster
DC Field | Value | Language |
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dc.contributor.author | Lyoo, In Kyoon | - |
dc.contributor.author | Kim, Jieun E. | - |
dc.contributor.author | Yoon, Sujung J. | - |
dc.contributor.author | Hwang, Jaeuk | - |
dc.contributor.author | Bae, Sujin | - |
dc.contributor.author | Kim, Dajung J. | - |
dc.date.accessioned | 2021-08-12T05:26:17Z | - |
dc.date.available | 2021-08-12T05:26:17Z | - |
dc.date.issued | 2011-07 | - |
dc.identifier.issn | 0003-990X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/16383 | - |
dc.description.abstract | Context: A multiwave longitudinal neuroimaging study in a cohort of direct survivors of a South Korean subway disaster, most of whom recovered from posttraumatic stress disorder 5 years after trauma, provided a unique opportunity to investigate the brain correlates of recovery from a severe psychological trauma. Objectives: To investigate region-specific brain mobilization during successful recovery from posttraumatic stress disorder by assessing cortical thickness multiple times from early after trauma to recovery, and to examine whether a brain-derived neurotrophic factor gene polymorphism was associated with this brain mobilization. Design: Five-year follow-up case-control study conducted from 2003-2007. Setting: Seoul National University and Hospital. Participants: Thirty psychologically traumatized disaster survivors and 36 age- and sex-matched control group members recruited from the disaster registry and local community, respectively, who contributed 156 high-resolution brain magnetic resonance images during 3 waves of assessments. Main Outcome Measures: Cerebral cortical thickness measured in high-resolution anatomic magnetic resonance images using a validated cortical thickness analysis tool and its prospective changes from early after trauma to recovery in trauma-exposed individuals and controls. Results: Trauma-exposed individuals had greater dorsolateral prefrontal cortical (DLPFC) thickness 1.42 years after trauma (right DLPFC, 5.4%; left superior frontal cortex, 5.8%; and left inferior frontal cortex, 5.3% [all clusters, P <= .011) relative to controls. Thicknesses gradually normalized over time during recovery. We found a positive linear trend, with trauma-exposed individuals with a valine/valine genotype having the greatest DLPFC cortical thickness, followed by those with a methionine genotype and controls (P < .001 for trend). Greater DLPFC thickness was associated with greater posttraumatic stress disorder symptom reductions and better recovery. Conclusion: The DLPFC region might play an important role in psychological recovery from a severely traumatic event in humans. | - |
dc.format.extent | 13 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | American Medical Association | - |
dc.title | The Neurobiological Role of the Dorsolateral Prefrontal Cortex in Recovery From Trauma Longitudinal Brain Imaging Study Among Survivors of the South Korean Subway Disaster | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1001/archgenpsychiatry.2011.70 | - |
dc.identifier.scopusid | 2-s2.0-79960314263 | - |
dc.identifier.wosid | 000292356600006 | - |
dc.identifier.bibliographicCitation | Archives of General Psychiatry, v.68, no.7, pp 701 - 713 | - |
dc.citation.title | Archives of General Psychiatry | - |
dc.citation.volume | 68 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 701 | - |
dc.citation.endPage | 713 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | ssci | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Psychiatry | - |
dc.relation.journalWebOfScienceCategory | Psychiatry | - |
dc.subject.keywordPlus | POSTTRAUMATIC-STRESS-DISORDER | - |
dc.subject.keywordPlus | BDNF VAL66MET POLYMORPHISM | - |
dc.subject.keywordPlus | ANTERIOR CINGULATE CORTEX | - |
dc.subject.keywordPlus | ACTIVITY-DEPENDENT SECRETION | - |
dc.subject.keywordPlus | ADMINISTERED PTSD SCALE | - |
dc.subject.keywordPlus | SCRIPT-DRIVEN IMAGERY | - |
dc.subject.keywordPlus | 3-YEAR FOLLOW-UP | - |
dc.subject.keywordPlus | NEUROTROPHIC FACTOR | - |
dc.subject.keywordPlus | CORTICAL THICKNESS | - |
dc.subject.keywordPlus | CEREBRAL-CORTEX | - |
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