Novel approach to the fabrication of an artificial small bone using a combination of sponge replica and electrospinning
DC Field | Value | Language |
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dc.contributor.author | Kim, Yang-Hee | - |
dc.contributor.author | Lee, Byong-Taek | - |
dc.date.accessioned | 2021-08-12T05:27:24Z | - |
dc.date.available | 2021-08-12T05:27:24Z | - |
dc.date.issued | 2011-06 | - |
dc.identifier.issn | 1468-6996 | - |
dc.identifier.issn | 1878-5514 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/16493 | - |
dc.description.abstract | In this study, a novel artificial small bone consisting of ZrO2-biphasic calcium phosphate/polymethylmethacrylate-polycaprolactone-hydroxyapatite (ZrO2-BCP/PMMA-PCL-HAp) was fabricated using a combination of sponge replica and electrospinning methods. To mimic the cancellous bone, the ZrO2/BCP scaffold was composed of three layers, ZrO2, ZrO2/BCP and BCP, fabricated by the sponge replica method. The PMMA-PCL fibers loaded with HAp powder were wrapped around the ZrO2/BCP scaffold using the electrospinning process. To imitate the Haversian canal region of the bone, HAp-loaded PMMA-PCL fibers were wrapped around a steel wire of 0.3 mm diameter. As a result, the bundles of fiber wrapped around the wires imitated the osteon structure of the cortical bone. Finally, the ZrO2/BCP scaffold was surrounded by HAp-loaded PMMA-PCL composite bundles. After removal of the steel wires, the ZrO2/BCP scaffold and bundles of HAp-loaded PMMA-PCL formed an interconnected structure resembling the human bone. Its diameter, compressive strength and porosity were approximately 12 mm, 5MPa and 70%, respectively, and the viability of MG-63 osteoblast-like cells was determined to be over 90% by the MTT (3-(4,5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide) assay. This artificial bone shows excellent cytocompatibility and is a promising bone regeneration material. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | National Institute for Materials Science and Elsevier BV Japan | - |
dc.title | Novel approach to the fabrication of an artificial small bone using a combination of sponge replica and electrospinning | - |
dc.type | Article | - |
dc.publisher.location | 영국 | - |
dc.identifier.doi | 10.1088/1468-6996/12/3/035002 | - |
dc.identifier.scopusid | 2-s2.0-79960251435 | - |
dc.identifier.wosid | 000295824500019 | - |
dc.identifier.bibliographicCitation | Science and Technology of Advanced Materials, v.12, no.3 | - |
dc.citation.title | Science and Technology of Advanced Materials | - |
dc.citation.volume | 12 | - |
dc.citation.number | 3 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.subject.keywordPlus | MECHANICAL-PROPERTIES | - |
dc.subject.keywordPlus | CANCELLOUS BONE | - |
dc.subject.keywordPlus | BCP NANOPOWDERS | - |
dc.subject.keywordPlus | CORTICAL BONE | - |
dc.subject.keywordPlus | NANOCOMPOSITE | - |
dc.subject.keywordPlus | SUBSTITUTES | - |
dc.subject.keywordPlus | COMPOSITES | - |
dc.subject.keywordPlus | NANOFIBERS | - |
dc.subject.keywordPlus | OSTEOBLAST | - |
dc.subject.keywordPlus | STIFFNESS | - |
dc.subject.keywordAuthor | artificial bone | - |
dc.subject.keywordAuthor | sponge replica | - |
dc.subject.keywordAuthor | electrospinning | - |
dc.subject.keywordAuthor | ZrO2-BCP/PMMA-PCL-HAp | - |
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