Alteration in NCX-3 immunoreactivity within the gerbil hippocampus following spontaneous seizures
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Dae-Kyoon | - |
dc.contributor.author | Park, Kyung-Ho | - |
dc.contributor.author | Ko, Jeong-Sik | - |
dc.contributor.author | Kim, Duk-Soo | - |
dc.date.accessioned | 2021-08-12T05:44:16Z | - |
dc.date.available | 2021-08-12T05:44:16Z | - |
dc.date.issued | 2011-05-31 | - |
dc.identifier.issn | 1976-6696 | - |
dc.identifier.issn | 1976-670X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/16534 | - |
dc.description.abstract | Although NCX-3 is highly expressed in the brain, the distribution of NCX-3 in the epileptic hippocampus is still controversial. Therefore, to assess the distribution and pattern of NCX-3 expression in epileptic hippocampus, we performed a comparative analysis of NCX-3 immunoreactivities in the hippocampus of seizure-resistant (SR) and seizure-sensitive (SS) gerbils. In SR gerbils, NCX-3 immunoreactivity was higher than pre-seizure SS gerbils, particularly in the pavalbumin (PV)-positive interneurons. Three h post-ictal, NCX-3 immunoreactivity in the SS gerbil hippocampus was markedly elevated to the level of SR gerbils. Six h post-ictal, the expression of NCX-3 was reduced to the level of pre-seizure SS gerbils. Therefore, the results of the present study suggest that down-regulation of NCX-3 expression in the SS gerbil hippocampus may be involved in the hyperexcitability of SS gerbils due to an imbalance of intracellular Na+/Ca2+ homeostasis and Ca2+ concentration. [BMB reports 2011; 44(5): 306-311] | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 생화학분자생물학회 | - |
dc.title | Alteration in NCX-3 immunoreactivity within the gerbil hippocampus following spontaneous seizures | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.5483/BMBRep.2011.44.5.306 | - |
dc.identifier.scopusid | 2-s2.0-79958710695 | - |
dc.identifier.wosid | 000291421900003 | - |
dc.identifier.bibliographicCitation | BMB Reports, v.44, no.5, pp 306 - 311 | - |
dc.citation.title | BMB Reports | - |
dc.citation.volume | 44 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 306 | - |
dc.citation.endPage | 311 | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001554333 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.subject.keywordPlus | RECEPTOR-MEDIATED REGULATION | - |
dc.subject.keywordPlus | SODIUM-CALCIUM EXCHANGE | - |
dc.subject.keywordPlus | NA+/CA2+ EXCHANGER | - |
dc.subject.keywordPlus | DENTATE GYRUS | - |
dc.subject.keywordPlus | NEURONS | - |
dc.subject.keywordPlus | INVOLVEMENT | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | PROTEINS | - |
dc.subject.keywordPlus | INFLUX | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordAuthor | Epilepsy | - |
dc.subject.keywordAuthor | Gerbil | - |
dc.subject.keywordAuthor | Hippocampus | - |
dc.subject.keywordAuthor | Immunohistochemistry | - |
dc.subject.keywordAuthor | Na+/Ca2+ exchanger (NCX) | - |
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