The roles of fractalkine/CX3CR1 system in neuronal death following pilocarpine-induced status epilepticus
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yeo, S. -I. | - |
dc.contributor.author | Kim, J. -E. | - |
dc.contributor.author | Ryu, H. J. | - |
dc.contributor.author | Seo, C. H. | - |
dc.contributor.author | Lee, B. C. | - |
dc.contributor.author | Choi, I. -G. | - |
dc.contributor.author | Kim, D. -S. | - |
dc.contributor.author | Kang, T. -C. | - |
dc.date.accessioned | 2021-08-12T05:44:54Z | - |
dc.date.available | 2021-08-12T05:44:54Z | - |
dc.date.issued | 2011-05 | - |
dc.identifier.issn | 0165-5728 | - |
dc.identifier.issn | 1872-8421 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/16576 | - |
dc.description.abstract | Although fractalkine is one of chemokines involved in mediation of neuronal/microglial interaction, it is not known whether fractalkine/CX3CR1-mediated pathogenesis occurs in the rat brain following epileptogenic insults. In order to elucidate the roles of the fractalkine/CX3CR1 system in microglial activation and neurodegeneration induced by status epilepticus (SE), we investigated changes in fractalkine/CX3CR1 system within the rat hippocampus following SE. In non-SE induced animals, fractalkine and CX3CR1 immunoreactivity was detected in neurons and microglia, respectively. Following SE, fractalkine immunoreactivity was transiently increased in neurons and astrocytes. CX3CR1 immunoreactivity was also transiently detected in neurons (particularly in CA1 pyramidal cells). Intracerebroventricular infusions of recombinant rat fractalkine aggravated SE-induced neuronal damage, while fractalkine IgG or CX3CR1 IgG infusion alleviated it, compared to saline-infused animals. These findings suggest that fractalkine/CX3CR1 system may play an important role in SE-induced neuronal damages via neuron-microglial interactions. (C) 2011 Elsevier B.V. All rights reserved. | - |
dc.format.extent | 10 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Elsevier BV | - |
dc.title | The roles of fractalkine/CX3CR1 system in neuronal death following pilocarpine-induced status epilepticus | - |
dc.type | Article | - |
dc.publisher.location | 네델란드 | - |
dc.identifier.doi | 10.1016/j.jneuroim.2011.03.005 | - |
dc.identifier.scopusid | 2-s2.0-79955659802 | - |
dc.identifier.wosid | 000291521600011 | - |
dc.identifier.bibliographicCitation | Journal of Neuroimmunology, v.234, no.1-2, pp 93 - 102 | - |
dc.citation.title | Journal of Neuroimmunology | - |
dc.citation.volume | 234 | - |
dc.citation.number | 1-2 | - |
dc.citation.startPage | 93 | - |
dc.citation.endPage | 102 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.subject.keywordPlus | TEMPORAL-LOBE EPILEPSY | - |
dc.subject.keywordPlus | RAT HIPPOCAMPAL-NEURONS | - |
dc.subject.keywordPlus | CENTRAL-NERVOUS-SYSTEM | - |
dc.subject.keywordPlus | MAGNETIC-RESONANCE | - |
dc.subject.keywordPlus | DENTATE GYRUS | - |
dc.subject.keywordPlus | ELECTRICAL STIMULATION | - |
dc.subject.keywordPlus | MICROGLIAL ACTIVATION | - |
dc.subject.keywordPlus | NEUROPATHIC PAIN | - |
dc.subject.keywordPlus | SEIZURE ACTIVITY | - |
dc.subject.keywordPlus | CELL NUMBERS | - |
dc.subject.keywordAuthor | Fractalkine | - |
dc.subject.keywordAuthor | CX3CR1 | - |
dc.subject.keywordAuthor | Neutralization | - |
dc.subject.keywordAuthor | Microglia | - |
dc.subject.keywordAuthor | Epilepsy | - |
dc.subject.keywordAuthor | Hippocampus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(31538) 22, Soonchunhyang-ro, Asan-si, Chungcheongnam-do, Republic of Korea+82-41-530-1114
COPYRIGHT 2021 by SOONCHUNHYANG UNIVERSITY ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.