Suppression of cyclooxygenase-2 expression induced by Toll-like receptor 2 or 4 agonists by (E)-isopropyl 4-oxo-4-(2-oxopyrrolidin-1-yl)-2-butenoate
DC Field | Value | Language |
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dc.contributor.author | Lee, A-Neum | - |
dc.contributor.author | Park, Se-Jeong | - |
dc.contributor.author | Koh, Kwang Oh | - |
dc.contributor.author | Kim, Dae Young | - |
dc.contributor.author | Youn, Hyung-Sun | - |
dc.date.accessioned | 2021-08-12T05:45:56Z | - |
dc.date.available | 2021-08-12T05:45:56Z | - |
dc.date.issued | 2011-03-31 | - |
dc.identifier.issn | 1738-642X | - |
dc.identifier.issn | 2092-8467 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/16635 | - |
dc.description.abstract | Inflammation can be initiated by invading microbial pathogens. Toll-like receptors (TLRs) recognize molecular structures derived from microbial pathogens and regulate the activation of innate immunity. TLR signaling pathways trigger the activation of nuclear factor-kappa B (NF-kappa B) transcription factor, leading to the induction of inflammatory gene products such as cyclooxygenase-2. Here, we present biochemical evidence that the fumaryl pyrroliclinone, (E)-isopropyl 4-oxo-4-(2-oxopyrrolidin-1-yl)-2-butenoate (IPOP), previously synthesized in our laboratory inhibits NF-kappa B activation induced by TLR agonists and overexpression of two downstream signaling components of TLRs. IPOP also inhibits TLR agonist-induced expression of cyclooxygenase-2. Our results suggest that IPOP can modulate TLR-mediated inflammatory responses and, potentially, the risk of many chronic inflammatory diseases. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 대한독성 유전단백체 학회 | - |
dc.title | Suppression of cyclooxygenase-2 expression induced by Toll-like receptor 2 or 4 agonists by (E)-isopropyl 4-oxo-4-(2-oxopyrrolidin-1-yl)-2-butenoate | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.1007/s13273-011-0006-0 | - |
dc.identifier.scopusid | 2-s2.0-79960104917 | - |
dc.identifier.wosid | 000289120400006 | - |
dc.identifier.bibliographicCitation | Molecular & Cellular Toxicology, v.7, no.1, pp 39 - 44 | - |
dc.citation.title | Molecular & Cellular Toxicology | - |
dc.citation.volume | 7 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 39 | - |
dc.citation.endPage | 44 | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001543172 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kciCandi | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Toxicology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Toxicology | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordAuthor | Toll-like receptor | - |
dc.subject.keywordAuthor | Lipopolysaccharide | - |
dc.subject.keywordAuthor | Cyclooxygenase-2 | - |
dc.subject.keywordAuthor | Nuclear factor-kappa B | - |
dc.subject.keywordAuthor | Fumaryl pyrrolidinone | - |
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