Genetic diversity of a Korean echovirus 5 isolate and response of the strain to five antiviral drugs
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Kwisung | - |
dc.contributor.author | Song, Jaehyoung | - |
dc.contributor.author | Baek, Kyoungah | - |
dc.contributor.author | Lee, Changgyun | - |
dc.contributor.author | Kim, Donguk | - |
dc.contributor.author | Cho, SamHyun | - |
dc.contributor.author | Park, JoonSoo | - |
dc.contributor.author | Choi, YoungJin | - |
dc.contributor.author | Kang, Byunghak | - |
dc.contributor.author | Choi, Hwajung | - |
dc.contributor.author | Cheon, Doo-Sung | - |
dc.date.accessioned | 2021-08-12T05:46:53Z | - |
dc.date.available | 2021-08-12T05:46:53Z | - |
dc.date.issued | 2011-02-24 | - |
dc.identifier.issn | 1743-422X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/16704 | - |
dc.description.abstract | An outbreak of echovirus 5 (ECV 5) occurred in Korea in 2006, marking the first time this virus had been identified in the country since enterovirus surveillance began in 1993. Using a sample isolated from a young male patient with aseptic meningitis, we performed sequencing of the Korean ECV 5 strain and compared it with a prototype strain (Noyce). At the nucleotide level, the P1 region (85.3%) had the highest identity value; at the amino acid level, the P3 region (98.0%) had the highest identity value. The two strains shared all cleavage sites, with the exception of the VP1/2A site, which was TY/GA in the Noyce strain but TR/GA in the Korean ECV 5 isolate. In Vero cells infected with the Korean ECV 5 isolate, no cytotoxicity was observed in the presence of azidothymidine, acyclovir, amantadine, lamivudine, or ribavirin, when the drugs were administered at a CC50 value > 100 mu g/mL. Of the five drugs, only amantadine (IC50: 1 +/- 0.42 mu g/mL, TI: 100) and ribavirin (IC50: 22 +/- 1.36 mu g/mL, TI: 4.55) had any antiviral activity against the Korean ECV 5 isolate. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | BioMed Central | - |
dc.title | Genetic diversity of a Korean echovirus 5 isolate and response of the strain to five antiviral drugs | - |
dc.type | Article | - |
dc.publisher.location | 영국 | - |
dc.identifier.doi | 10.1186/1743-422X-8-79 | - |
dc.identifier.scopusid | 2-s2.0-79951855160 | - |
dc.identifier.wosid | 000288425600001 | - |
dc.identifier.bibliographicCitation | Virology Journal, v.8 | - |
dc.citation.title | Virology Journal | - |
dc.citation.volume | 8 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Virology | - |
dc.relation.journalWebOfScienceCategory | Virology | - |
dc.subject.keywordPlus | ENTEROVIRUSES | - |
dc.subject.keywordPlus | VIRUSES | - |
dc.subject.keywordPlus | CLASSIFICATION | - |
dc.subject.keywordPlus | RECOMBINATION | - |
dc.subject.keywordPlus | REPLICATION | - |
dc.subject.keywordPlus | PLECONARIL | - |
dc.subject.keywordPlus | EVOLUTION | - |
dc.subject.keywordPlus | SEQUENCE | - |
dc.subject.keywordPlus | ASSAY | - |
dc.subject.keywordPlus | MICE | - |
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