In Vitro and In Vivo Evaluations of 3D Porous TCP-coated and Non-coated Alumina Scaffolds
DC Field | Value | Language |
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dc.contributor.author | Kim, Young-Hee | - |
dc.contributor.author | Anirban, Jyoti M. | - |
dc.contributor.author | Song, Ho-Yeon | - |
dc.contributor.author | Seo, Hyung-Seok | - |
dc.contributor.author | Lee, Byong-Taek | - |
dc.date.accessioned | 2021-08-12T05:47:25Z | - |
dc.date.available | 2021-08-12T05:47:25Z | - |
dc.date.issued | 2011-02 | - |
dc.identifier.issn | 0885-3282 | - |
dc.identifier.issn | 1530-8022 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/16746 | - |
dc.description.abstract | Both tricalcium phosphate (TCP) and alumina have been extensively studied and shown to have high biocompatibility. Tricalcium phosphate has improved biodegradability and a higher solubility than hydroxyapatite. In contrast, alumina (Al2O3) is almost completely inert at physiological conditions and has been used as a biomaterial due to its wear resistance, high surface finish, and excellent hardness. Thus, the combination of these two implants would result in greater biocompatibility and phenotype maintenance. A polyurethane (PU) foam replica method was employed in this study to coat TCP on an alumina scaffold. The TCP-coated alumina scaffold was then sintered to generate a porous surface morphology. The pore sizes obtained using this approach ranged between 100-600 mu m, which is ideal for cellular proliferation. The cytotoxicity, cellular proliferation, differentiation, and ECM deposition on the coated scaffold resulted in longer-term viability of osteogenic markers compared to the non-coated scaffold. Moreover, the osteogenic properties of porous TCP-coated Al2O3 scaffolds were reported in this study using rabbit models. The TCP/Al2O3 scaffold and control Al2O3 scaffolds were implanted in the rabbit femur. The bone tissue response was analyzed with micro-computed tomography (micro CT) at 12 and 24 weeks after implantation. The porous scaffolds exhibited favorable hard and soft tissue responses at both time points. At 24 weeks, a three-fold increase in bone tissue ingrowth was observed in defects containing TCP-coated Al2O3 scaffolds compared to control Al2O3 scaffolds. | - |
dc.format.extent | 20 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | SAGE Publications | - |
dc.title | In Vitro and In Vivo Evaluations of 3D Porous TCP-coated and Non-coated Alumina Scaffolds | - |
dc.type | Article | - |
dc.publisher.location | 영국 | - |
dc.identifier.doi | 10.1177/0885328209356945 | - |
dc.identifier.scopusid | 2-s2.0-79951637121 | - |
dc.identifier.wosid | 000287238600002 | - |
dc.identifier.bibliographicCitation | Journal of Biomaterials Applications, v.25, no.6, pp 539 - 558 | - |
dc.citation.title | Journal of Biomaterials Applications | - |
dc.citation.volume | 25 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 539 | - |
dc.citation.endPage | 558 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Engineering, Biomedical | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.subject.keywordPlus | BONE | - |
dc.subject.keywordPlus | BEHAVIOR | - |
dc.subject.keywordPlus | HYDROXYAPATITE | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | CARBON | - |
dc.subject.keywordAuthor | tricalcium phosphate | - |
dc.subject.keywordAuthor | biocompatibility | - |
dc.subject.keywordAuthor | cytotoxicity | - |
dc.subject.keywordAuthor | ECMs | - |
dc.subject.keywordAuthor | micro-CT | - |
dc.subject.keywordAuthor | alumina scaffold | - |
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