Effect of Atorvastatin and Clopidogrel Co-Administration After Coronary Stenting in Korean Patients With Stable Angina
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Goeng Bae | - |
dc.contributor.author | Kim, Jeong Kyung | - |
dc.contributor.author | Park, Sul | - |
dc.contributor.author | Jeong, Jae Jin | - |
dc.contributor.author | Yoon, Hyung Sik | - |
dc.contributor.author | Ko, Sang Hun | - |
dc.contributor.author | Ko, Jae Ee | - |
dc.contributor.author | Park, Soo Jin | - |
dc.contributor.author | Nam, Seon Woo | - |
dc.contributor.author | Lee, Jae Hwan | - |
dc.contributor.author | Hyon, Min Soo | - |
dc.date.accessioned | 2021-08-12T05:48:33Z | - |
dc.date.available | 2021-08-12T05:48:33Z | - |
dc.date.issued | 2011-01 | - |
dc.identifier.issn | 1738-5520 | - |
dc.identifier.issn | 1738-5555 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/16820 | - |
dc.description.abstract | Background and Objectives: It was reported that atorvastatin co-administered with clopidogrel for 8 months did not affect the anti-platelet potency of clopidogrel in Korean patients with acute coronary syndrome, but not in patients with stable angina. We investigated whether co-administration of statins with clopidogrel affected the anti-platelet efficacy of clopidogrel in Korean patients with stable angina. Subjects and Methods: This was a randomized, open-label and two-period crossover design study conducted at two centers. Two hundreds thirty three patients with stable angina scheduled for coronary stenting were randomized into two groups. In Group A, 119 patients first received atorvastatin (10 mg) followed by fluvastatin (80 mg) for 12 weeks per treatment. In Group B, 114 patients received the same treatments in reverse order. Results: Baseline adenosine diphosphate (ADP, 10 mu mol/L)-induced platelet aggregation was 54.4+/-9.1% in Group A and 53.8+/-9.0% in Group B (p=0.44), and significant differences were noted after each treatment period (p<0.001). Inhibition of platelet aggregation was similar between Group A and Group B at 24 hours following clopidogrel loading (29.2+/-11.0% vs. 30.4+/-12.7%; p=0.42). The two treatment least square means of 12-week ADP (10 mu mol/L)-induced platelet aggregation [29.50+/-0.79 {standard error (SE)}% on the atorvastatin treatment group vs. 28.16+/-0.70 (SE)% in the fluvastatin treatment group] in a 2x2 cross-over study were not significantly different (p=0.204). Conclusion: Statin and clopidogrel co-administration for 12 weeks is not associated with attenuated anti-platelet activity of clopidogrel in Korean patients with stable angina after coronary stenting, in support of the findings of similar studies conducted in Caucasian populations. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 대한심장학회 | - |
dc.title | Effect of Atorvastatin and Clopidogrel Co-Administration After Coronary Stenting in Korean Patients With Stable Angina | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.4070/kcj.2011.41.1.28 | - |
dc.identifier.scopusid | 2-s2.0-79952344114 | - |
dc.identifier.wosid | 000209078200006 | - |
dc.identifier.bibliographicCitation | Korean Circulation Journal, v.41, no.1, pp 28 - 33 | - |
dc.citation.title | Korean Circulation Journal | - |
dc.citation.volume | 41 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 28 | - |
dc.citation.endPage | 33 | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001531336 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Cardiovascular System & Cardiology | - |
dc.relation.journalWebOfScienceCategory | Cardiac & Cardiovascular Systems | - |
dc.subject.keywordAuthor | Clopidogrel | - |
dc.subject.keywordAuthor | Cardiovascular diseases | - |
dc.subject.keywordAuthor | Cytochrome P450 3A4 protein, human | - |
dc.subject.keywordAuthor | Atorvastatin | - |
dc.subject.keywordAuthor | Stents | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(31538) 22, Soonchunhyang-ro, Asan-si, Chungcheongnam-do, Republic of Korea+82-41-530-1114
COPYRIGHT 2021 by SOONCHUNHYANG UNIVERSITY ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.