Inhibitory effect of antioxidants on the benz[a]anthracene-induced oxidative DNA damage in lymphocyte
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Seo, Yoo-Na | - |
dc.contributor.author | Lee, Mi-Young | - |
dc.date.accessioned | 2021-08-12T05:48:37Z | - |
dc.date.available | 2021-08-12T05:48:37Z | - |
dc.date.issued | 2011-01 | - |
dc.identifier.issn | 0254-8704 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/16824 | - |
dc.description.abstract | Benz[a]anthracene is a ubiquitous environmental contaminant formed during the incomplete combustion of organic material. Some of the metabolites of benz[a]anthracene are known to be toxic and carcinogenic. In this investigation, benz[a]anthracene-induced oxidative damage to lymphocyte DNA was evaluated with the Comet assay (single cell gel electrophoresis). The level of oxidative DNA damage caused by benz[a]anthracene increased in a dose-dependent manner (24,49) and oxidative DNA damage was significantly inhibited by 5 and 10 mu g ml(-1) ascorb ate, 5 mu g ml(-1) polyphenols, as well as 5 and 10 mu g ml(-1) curcumin. Moreover, traditional Korean medicinal herbs such as Acanthopanax and ginseng significantly reduced DNA damage. The results demonstrate that antioxidant supplementation to lymphocytes inhibits oxidative DNA damage in vitro, supporting an inhibitory effect against oxidative DNA damage, probably due to reduction of reactive oxygen species production induced by benz[a]anthracene. | - |
dc.format.extent | 4 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Academy of Environmental Biology | - |
dc.title | Inhibitory effect of antioxidants on the benz[a]anthracene-induced oxidative DNA damage in lymphocyte | - |
dc.type | Article | - |
dc.publisher.location | 인도 | - |
dc.identifier.scopusid | 2-s2.0-79955816939 | - |
dc.identifier.wosid | 000286170500002 | - |
dc.identifier.bibliographicCitation | Journal of Environmental Biology, v.32, no.1, pp 7 - 10 | - |
dc.citation.title | Journal of Environmental Biology | - |
dc.citation.volume | 32 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 7 | - |
dc.citation.endPage | 10 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Environmental Sciences & Ecology | - |
dc.relation.journalWebOfScienceCategory | Environmental Sciences | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | TOXICITY | - |
dc.subject.keywordPlus | GINSENG | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | GINSENOSIDES | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | CURCUMIN | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | PART | - |
dc.subject.keywordPlus | RAT | - |
dc.subject.keywordAuthor | Benz[a]anthracene | - |
dc.subject.keywordAuthor | Comet assay | - |
dc.subject.keywordAuthor | Oxidative DNA damage | - |
dc.subject.keywordAuthor | Antioxidant | - |
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