Treatment with Bisphenol A Leads to the Promotion of Human Breast Cancer Cells and Alteration of Cell Cycle-Related Gene Expressions, cyclin E and p27
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이혜림 | - |
dc.contributor.author | 김태희 | - |
dc.contributor.author | 최경철 | - |
dc.date.accessioned | 2021-08-12T06:25:52Z | - |
dc.date.available | 2021-08-12T06:25:52Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 2508-1357 | - |
dc.identifier.issn | 2508-139X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/16979 | - |
dc.description.abstract | Endocrine disrupting chemicals (EDCs) have detrimental effects on human health. Among these EDCs, bisphenol A (BPA) binds to the estrogen receptors (ERs) to stimulate estrogen-mediated responses. BPA is assumed to disrupt reproductive and development system on human. In addition, BPA has been suspected as a risk of carcinogenesis recently. Because BPA can cause abnormal estrogen-mediated response in the organism, the exposure to BPA may stimulate the growth of estrogen-dependent breast cancers in human. In breast cancer, cyclin E and cyclin-dependent kinase inhibitor p27 are important in G1/S phase transition during the cell cycle progression. In this study, we investigated the effect of BPA on the proliferation of MCF-7 breast cancer cells in vitro using an MTT assay. Also, we analyzed the transcriptional levels of cyclin E and p27 following BPA treatment using semi-quantitative RT-PCR. As a result, BPA significantly induced the breast cancer cell growth compared to a vehicle. BPA caused the alterations of cyclin E and p27 mRNA expressions. The expression of cyclin E was increased by BPA, while p27 was decreased at 24 h after treatment of BPA in MCF-7 breast cancer cells. Taken together, these collective results suggest that the exposure of BPA induced breast cancer cell proliferation with deregulation of cell cycle. A further study is required to determine effects of BPA on carcinogenic process in in vivo models. | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 동물의학연구소 | - |
dc.title | Treatment with Bisphenol A Leads to the Promotion of Human Breast Cancer Cells and Alteration of Cell Cycle-Related Gene Expressions, cyclin E and p27 | - |
dc.title.alternative | Treatment with Bisphenol A Leads to the Promotion of Human Breast Cancer Cells and Alteration of Cell Cycle-Related Gene Expressions, cyclin E and p27 | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.bibliographicCitation | Journal of Biomedical and Translational Research, v.12, no.4, pp 215 - 223 | - |
dc.citation.title | Journal of Biomedical and Translational Research | - |
dc.citation.volume | 12 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 215 | - |
dc.citation.endPage | 223 | - |
dc.identifier.kciid | ART001643044 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | kciCandi | - |
dc.subject.keywordAuthor | Endocrine disruption | - |
dc.subject.keywordAuthor | Bisphenol A | - |
dc.subject.keywordAuthor | Human breast cancer | - |
dc.subject.keywordAuthor | Cyclin E | - |
dc.subject.keywordAuthor | p27 | - |
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