Clinical significance of occult hepatitis B virus infection in chronic hepatitis C patients
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 장재영 | - |
dc.contributor.author | 정승원 | - |
dc.contributor.author | 전성란 | - |
dc.contributor.author | 이세환 | - |
dc.contributor.author | 김상균 | - |
dc.contributor.author | 천영국 | - |
dc.contributor.author | 김영석 | - |
dc.contributor.author | 조영덕 | - |
dc.contributor.author | 김홍수 | - |
dc.contributor.author | 진소영 | - |
dc.contributor.author | 김연수 | - |
dc.contributor.author | 김부성 | - |
dc.date.accessioned | 2021-08-12T06:27:33Z | - |
dc.date.available | 2021-08-12T06:27:33Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 2287-2728 | - |
dc.identifier.issn | 2287-285X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/17106 | - |
dc.description.abstract | Background/Aims: We investigated the frequency of occult hepatitis B virus (HBV) infection in anti-hepatitis C virus (HCV)-positive individuals and the effects of occult HBV infection on the severity of liver disease. Methods: Seventy-one hepatitis B virus surface-antigen (HBsAg)-negative patients were divided according to their HBV serological status into groups A (anti-HBc positive, anti-HBs negative; n=18), B (anti-HBc positive, anti-HBs positive; n=34), and C (anti-HBc negative, anti-HBs positive/negative; n=19), and by anti-HCV positivity (anti-HCV positive; n=32 vs. anti-HCV negative; n=39). Liver biopsy samples were taken, and HBV DNA was quantified by real-time PCR. Results: Intrahepatic HBV DNA was detected in 32.4% (23/71) of the entire cohort, and HBV DNA levels were invariably low in the different groups. Occult HBV infection was detected more frequently in the anti-HBc-positive patients. Intrahepatic HBV DNA was detected in 28.1% (9/32) of the anti-HCV-positive and 35.9% (14/39) of the anti-HCV-negative subjects. The HCV genotype did not affect the detection rate of intrahepatic HBV DNA. In anti-HCV-positive cases, occult HBV infection did not affect liver disease severity. Conclusions: Low levels of intrahepatic HBV DNA were detected frequently in both HBsAg-negative and anti-HCV-positive cases. However, the frequency of occult HBV infection was not affected by the presence of hepatitis C, and occult HBV infection did not have a significant effect on the disease severity of hepatitis C. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 대한간학회 | - |
dc.title | Clinical significance of occult hepatitis B virus infection in chronic hepatitis C patients | - |
dc.title.alternative | Clinical significance of occult hepatitis B virus infection in chronic hepatitis C patients | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.bibliographicCitation | Clinical and Molecular Hepatology, v.17, no.3, pp 206 - 212 | - |
dc.citation.title | Clinical and Molecular Hepatology | - |
dc.citation.volume | 17 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 206 | - |
dc.citation.endPage | 212 | - |
dc.identifier.kciid | ART001587327 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | kci | - |
dc.subject.keywordAuthor | Occult infection | - |
dc.subject.keywordAuthor | Hepatitis B virus | - |
dc.subject.keywordAuthor | Hepatitis C virus | - |
dc.subject.keywordAuthor | HBV DNA | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(31538) 22, Soonchunhyang-ro, Asan-si, Chungcheongnam-do, Republic of Korea+82-41-530-1114
COPYRIGHT 2021 by SOONCHUNHYANG UNIVERSITY ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.