Animal Models of Periventricular LeukomalaciaAnimal Models of Periventricular Leukomalacia
- Other Titles
- Animal Models of Periventricular Leukomalacia
- Authors
- 최은경; 박동선; 김태균; 이선희; 배대권; 양고은; 양윤희; 경장빈; 김다정; 이우령; 서준교; 정은석; 김승유; 김윤배
- Issue Date
- 2011
- Publisher
- 한국실험동물학회
- Keywords
- Periventricular leukomalacia; white matter injury; cerebral palsy; hypoperfusion (hypoxia-ischemia); inflammation (lipopolysaccharide); premyelinating oligodendrocytes
- Citation
- Laboratory Animal Research, v.27, no.2, pp 77 - 84
- Pages
- 8
- Journal Title
- Laboratory Animal Research
- Volume
- 27
- Number
- 2
- Start Page
- 77
- End Page
- 84
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/17178
- ISSN
- 1738-6055
2233-7660
- Abstract
- Periventricular leukomalacia, specifically characterized as white matter injury, in neonates is strongly associated with the damage of pre-myelinating oligodendrocytes. Clinical data suggest that hypoxiaischemia during delivery and intrauterine or neonatal infection-inflammation are important factors in the etiology of periventricular leukomalacia including cerebral palsy, a serious case exhibiting neurobehavioral deficits of periventricular leukomalacia. In order to explore the pathophysiological mechanisms of white matter injury and to better understand how infectious agents may affect the vulnerability of the immature brain to injury, novel animal models have been developed using hypoperfusion, microbes or bacterial products (lipopolysaccharide) and excitotoxins. Such efforts have developed rat models that produce predominantly white matter lesions by adopting combined hypoxia-ischemia technique on postnatal days 1-7, in which unilateral or bilateral carotid arteries of animals are occluded (ischemia) followed by 1-2hour exposure to 6-8% oxygen environment (hypoxia). Furthermore, low doses of lipopolysaccharide that by themselves have no adverse-effects in 7-day-old rats, dramatically increase brain injury to hypoxicischemic challenge, implying that inflammation sensitizes the immature central nervous system.
Therefore, among numerous models of periventricular leukomalacia, combination of hypoxia-ischemialipopolysaccharide might be one of the most-acceptable rodent models to induce extensive white matter injury and ensuing neurobehavioral deficits for the evaluation of candidate therapeutics.
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Collections - College of Medicine > Department of Pediatrics > 1. Journal Articles
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