Neuroprotective Effect of the n-Hexane Extracts of Laurus nobilis L. in Models of Parkinson’s Disease
DC Field | Value | Language |
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dc.contributor.author | Ahrom Ham | - |
dc.contributor.author | 신종헌 | - |
dc.contributor.author | 오기봉 | - |
dc.contributor.author | 이성진 | - |
dc.contributor.author | 남궁우 | - |
dc.contributor.author | Uk Koo | - |
dc.contributor.author | 김경호 | - |
dc.contributor.author | 마응천 | - |
dc.date.accessioned | 2021-08-12T06:47:17Z | - |
dc.date.available | 2021-08-12T06:47:17Z | - |
dc.date.created | 2021-06-17 | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 1976-9148 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/17353 | - |
dc.description.abstract | Free radical scavenging and antioxidants have attracted attention as a way to prevent the progression of Parkinson’s disease (PD). This study was carried out to investigate the effects of n-hexane fraction from Laurus nobilis L. (Lauraceae) leaves (HFL) on dopamine (DA)-induced intracellular reactive oxygen species (ROS) production and apoptosis in human neuroblastoma SH-SY5Y cells. Compared with apomorphine (APO, IC_(50)=18.1 μM) as a positive control, the HFL IC_(50) value for DA-induced apoptosis was 3.0 μg/ml, and two major compounds from HFL, costunolide and dehydrocostus lactone, were 7.3 μM and 3.6 μM, respectively. HFL and these major compounds signifi cantly inhibited ROS generation in DA-induced SH-SY5Y cells. A rodent 6-hydroxydopamine (6-OHDA) model of PD was employed to investigate the potential neuroprotective effects of HFL in vivo. 6-OHDA was injected into the substantia nigra of young adult rats and an immunohistochemical analysis was conducted to quantitate the tyrosine hydroxylase (TH)-positive neurons. HFL signifi cantly inhibited 6-OHDA-induced TH-positive cell loss in the substantia nigra and also reduced DA induced α-synuclein (SYN) formation in SH-SY5Y cells. These results indicate that HFL may have neuroprotective effects against DA-induced in vitro and in vivo models of PD. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | 한국응용약물학회 | - |
dc.title | Neuroprotective Effect of the n-Hexane Extracts of Laurus nobilis L. in Models of Parkinson’s Disease | - |
dc.title.alternative | Neuroprotective Effect of the n-Hexane Extracts of Laurus nobilis L. in Models of Parkinson’s Disease | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | 남궁우 | - |
dc.identifier.bibliographicCitation | Biomolecules & Therapeutics, v.19, no.1, pp.118 - 125 | - |
dc.relation.isPartOf | Biomolecules & Therapeutics | - |
dc.citation.title | Biomolecules & Therapeutics | - |
dc.citation.volume | 19 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 118 | - |
dc.citation.endPage | 125 | - |
dc.type.rims | ART | - |
dc.identifier.kciid | ART001522663 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.subject.keywordAuthor | Laurus nobilis L | - |
dc.subject.keywordAuthor | Dopamine | - |
dc.subject.keywordAuthor | Parkinson’s disease | - |
dc.subject.keywordAuthor | Neuroprotective | - |
dc.subject.keywordAuthor | α-synuclein | - |
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