Essential Oil of Thujopsis dolobrata Suppresses Atopic Dermatitis- Like Skin Lesions in NC/Nga Mice
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 남궁우 | - |
dc.contributor.author | Jae Kyu Noh | - |
dc.contributor.author | Su Kwan Kim | - |
dc.contributor.author | 이성진 | - |
dc.contributor.author | 김경호 | - |
dc.contributor.author | 오기봉 | - |
dc.contributor.author | Jongheon Shin | - |
dc.contributor.author | 마응천 | - |
dc.date.accessioned | 2021-08-12T06:47:18Z | - |
dc.date.available | 2021-08-12T06:47:18Z | - |
dc.date.created | 2021-06-17 | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 1976-9148 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/17354 | - |
dc.description.abstract | We examined the effects of essential oil from Thujopsis dolobrata Sieb. et Zucc. var. hondai Makino (EOTD) (Cupressaceae) on atopic dermatitis (AD)-like skin lesions in NC/Nga mice. Treatment with EOTD twice daily for two weeks ameliorate AD-like skin lesions induced by DNCB (2,4 dinitrochlorobenzene), and clinical scores were reduced to 7.29, 7.07, and 4.5 points in the groups treated with 1.5%, 3.0%, and 6.0% extract (p<0.01) respectively, from the 15.0 score obtained using vehicle. EOTD inhibited the infi ltration of mast cells into the AD-like skin lesion in NC/Nga mice (p<0.01) and also reduced serum histamine and IgE levels (p<0.05). Furthermore, it dose-dependently inhibited the release of beta-hexosaminidase from rat basophilic leukemia RBL 2H3cells. These results indicate that EOTD reduces AD-like skin lesions by inhibiting the production of IgE and histamine, and, thus,IgE-mediated degranulation. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | 한국응용약물학회 | - |
dc.title | Essential Oil of Thujopsis dolobrata Suppresses Atopic Dermatitis- Like Skin Lesions in NC/Nga Mice | - |
dc.title.alternative | Essential Oil of Thujopsis dolobrata Suppresses Atopic Dermatitis- Like Skin Lesions in NC/Nga Mice | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | 남궁우 | - |
dc.identifier.bibliographicCitation | Biomolecules & Therapeutics, v.19, no.1, pp.102 - 108 | - |
dc.relation.isPartOf | Biomolecules & Therapeutics | - |
dc.citation.title | Biomolecules & Therapeutics | - |
dc.citation.volume | 19 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 102 | - |
dc.citation.endPage | 108 | - |
dc.type.rims | ART | - |
dc.identifier.kciid | ART001522658 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.subject.keywordAuthor | Thujopsis dolobrata | - |
dc.subject.keywordAuthor | Atopic dermatitis | - |
dc.subject.keywordAuthor | Beta-hexosaminidase | - |
dc.subject.keywordAuthor | NC/Nga mouse | - |
dc.subject.keywordAuthor | IgE | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(31538) 22, Soonchunhyang-ro, Asan-si, Chungcheongnam-do, Republic of Korea+82-41-530-1114
COPYRIGHT 2021 by SOONCHUNHYANG UNIVERSITY ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.