Association Between Interleukin-3 Gene Polymorphism and Acute Rejection After Kidney Transplantation
DC Field | Value | Language |
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dc.contributor.author | Lee, D-Y. | - |
dc.contributor.author | Song, S-B. | - |
dc.contributor.author | Moon, J-Y. | - |
dc.contributor.author | Jeong, K-H. | - |
dc.contributor.author | Park, S. J. | - |
dc.contributor.author | Kim, H-J. | - |
dc.contributor.author | Kang, S. W. | - |
dc.contributor.author | Lee, S-H. | - |
dc.contributor.author | Kim, Y-H. | - |
dc.contributor.author | Chung, J-H. | - |
dc.contributor.author | Ihm, C-G. | - |
dc.contributor.author | Lee, T-W. | - |
dc.date.accessioned | 2021-08-12T06:58:08Z | - |
dc.date.available | 2021-08-12T06:58:08Z | - |
dc.date.issued | 2010-12 | - |
dc.identifier.issn | 0041-1345 | - |
dc.identifier.issn | 1873-2623 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/17470 | - |
dc.description.abstract | Backgrourd. Acute rejection (AR) after kidney transplantation resulting from alloimmune responses has a negative effect on graft survival. AR is mainly caused by T-cell immune responses activated by cytokines, including interleukin (IL)-2, -4, and -7. Many reports have shown that single nucleotide polymorphisms (SNPs) of these cytokines can affect the occurrence of AR. IL-3, which is secreted by activated T cells, can mediate AR. Our study sought to investigate the association between SNPs of the IL3 gene and the occurrence of an AR episode (ARE). Methods. We analyzed 3 SNPs of IL3 (rs181781, rs2073506, and rs40401) among 330 renal recipients, 60 of whom had developed an ARE. SNPs of the IL3 gene, including 1 exonic SNP (rs40401) and 2 regulatory thought to be promoter SNPs (rs181781 and rs2073506). Results. The genotypes of 60 ARE subjects and the 270 patients without AR demonstrated a significant relationship between genotype frequencies and the SNPs. The occurrence of an ARE was associated with rs181781 (P = .041, dominant model), rs2073506 (P = .009, codominant 1 model; P = .003, dominant model), and rs40401 (P = .014, recessive model). Among haplotypes, AAT showed a significant association with ARE. (P = .0033). Conclusion. Our results suggest that IL3 gene polymorphisms were associated with this event. | - |
dc.format.extent | 4 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Appleton & Lange | - |
dc.title | Association Between Interleukin-3 Gene Polymorphism and Acute Rejection After Kidney Transplantation | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1016/j.transproceed.2010.09.153 | - |
dc.identifier.scopusid | 2-s2.0-78650433149 | - |
dc.identifier.wosid | 000285732200141 | - |
dc.identifier.bibliographicCitation | Transplantation Proceedings, v.42, no.10, pp 4501 - 4504 | - |
dc.citation.title | Transplantation Proceedings | - |
dc.citation.volume | 42 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 4501 | - |
dc.citation.endPage | 4504 | - |
dc.type.docType | Article; Proceedings Paper | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalResearchArea | Surgery | - |
dc.relation.journalResearchArea | Transplantation | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.relation.journalWebOfScienceCategory | Surgery | - |
dc.relation.journalWebOfScienceCategory | Transplantation | - |
dc.subject.keywordPlus | ALLOGRAFT | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | POPULATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | GROWTH | - |
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