흰쥐 당뇨모델의 음경해면체에 이식된 인간 중간엽줄기세포 변화의 자기공명영상 추적관찰Monitoring Transplanted Human Mesenchymal Stem Cells in the Penile Cavernosal Tissues of Streptozotocin-induced Diabetic Rats Using Molecular Magnetic Resonance Imaging
- Other Titles
- Monitoring Transplanted Human Mesenchymal Stem Cells in the Penile Cavernosal Tissues of Streptozotocin-induced Diabetic Rats Using Molecular Magnetic Resonance Imaging
- Authors
- 송윤섭; 윤종현; 두승환; 양원재; 김정훈; 최동호; 김숙자; 정희정; 원종호
- Issue Date
- 2010
- Publisher
- 대한남성과학회
- Keywords
- Diabetes mellitus; MRI; Stem cells
- Citation
- The World Journal of Men's Health, v.28, no.3, pp 163 - 168
- Pages
- 6
- Journal Title
- The World Journal of Men's Health
- Volume
- 28
- Number
- 3
- Start Page
- 163
- End Page
- 168
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/18118
- ISSN
- 2287-4208
2287-4690
- Abstract
- Purpose: A molecular magnetic resonance (MR) imaging technique using superparamagnetic iron oxide (SPIO) nanocrystals was developed for monitoring stem cells noninvasively. This study was performed to investigate whether the presence of transplanted human mesenchymal stem cells in the penile cavernosum of a diabetic rat model could be evaluated noninvasively using molecular MR imaging.
Materials and Methods: SPIO nanocrystals (Feridex; AMI, Cambridge, USA) were transferred to human mesenchymal stem cells (hMSCs) using GenePORTER. The SPIO-transferred hMSCs were examined with Prussian blue staining. SPIO-labeled hMSCs were transplanted to the penile cavernosum of a diabetic rat model and MR images were examined in vivo using 1.5 T MR.
Results: SPIO was transferred to hMSCs successfully. MR signal intensity at the areas of the SPIO-transferred hMSCs decreased in the penile cavernosum of the diabetic rat model. SPIO particles were confirmed in the transplanted penile cavernosum with Prussian blue staining.
Conclusions: The SPIO-labelled hMSCs in the penile cavernosum of a diabetic rat model can be monitored noninvasively using molecular MR imaging.
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Collections - College of Medicine > Department of Urology > 1. Journal Articles
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