Parthenolide Suppresses the Expression of Cyclooxygenase-2 and Inducible Nitric Oxide Synthase Induced by Toll-Like Receptor 2 and 4 Agonists
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 윤형선 | - |
dc.contributor.author | 이아름 | - |
dc.contributor.author | 박세정 | - |
dc.contributor.author | 윤세미 | - |
dc.contributor.author | 이미영 | - |
dc.contributor.author | 손부순 | - |
dc.date.accessioned | 2021-08-12T07:33:39Z | - |
dc.date.available | 2021-08-12T07:33:39Z | - |
dc.date.created | 2021-06-17 | - |
dc.date.issued | 2010 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/18500 | - |
dc.description.abstract | Toll-like receptors (TLRs), which are pattern recognition receptors (PRRs), recognize pathogen-associated molecular patterns (PAMPs) and regulate the activation of innate immunity. All TLR signaling pathways culminate in the activation of NF-κB, leading to the induction of inflammatory gene products such as cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS). Parthenolide, a sesquiterpene lactone isolated from the herb feverfew (Tanacetum parthenium), has been used as folk remedies to treat many chronic diseases for many years. In the present report, we present biochemical evidence that parthenolide inhibits the NF-κB activation induced by TLR agonists and the overexpression of downstream signaling components of TLRs, MyD88, IKKβ, and p65. Parthenolide also inhibits TLR agonists-induced COX-2 and iNOS expression. These results suggest that parthenolide can modulate the immune responses regulated by TLR signaling pathways. | - |
dc.language | 한국어 | - |
dc.language.iso | ko | - |
dc.publisher | 대한의생명과학회 | - |
dc.title | Parthenolide Suppresses the Expression of Cyclooxygenase-2 and Inducible Nitric Oxide Synthase Induced by Toll-Like Receptor 2 and 4 Agonists | - |
dc.title.alternative | Parthenolide Suppresses the Expression of Cyclooxygenase-2 and Inducible Nitric Oxide Synthase Induced by Toll-Like Receptor 2 and 4 Agonists | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | 윤형선 | - |
dc.contributor.affiliatedAuthor | 이미영 | - |
dc.identifier.bibliographicCitation | 대한의생명과학회지, v.16, no.1, pp.39 - 45 | - |
dc.relation.isPartOf | 대한의생명과학회지 | - |
dc.citation.title | 대한의생명과학회지 | - |
dc.citation.volume | 16 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 39 | - |
dc.citation.endPage | 45 | - |
dc.type.rims | ART | - |
dc.identifier.kciid | ART001433167 | - |
dc.description.journalClass | 3 | - |
dc.subject.keywordAuthor | Toll-like receptors | - |
dc.subject.keywordAuthor | Parthenolide | - |
dc.subject.keywordAuthor | NF-κB | - |
dc.subject.keywordAuthor | COX-2 | - |
dc.subject.keywordAuthor | iNOS | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(31538) 22, Soonchunhyang-ro, Asan-si, Chungcheongnam-do, Republic of Korea+82-41-530-1114
COPYRIGHT 2021 by SOONCHUNHYANG UNIVERSITY ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.