PrPC Regulates the Cancer Stem Cell Properties via Interaction With c-Met in Colorectal Cancer Cells
DC Field | Value | Language |
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dc.contributor.author | Lim, Ji ho | - |
dc.contributor.author | Go, Gyeongyun | - |
dc.contributor.author | Lee, Sang hun | - |
dc.date.accessioned | 2021-09-10T05:45:13Z | - |
dc.date.available | 2021-09-10T05:45:13Z | - |
dc.date.issued | 2021-07 | - |
dc.identifier.issn | 0250-7005 | - |
dc.identifier.issn | 1791-7530 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/18717 | - |
dc.description.abstract | Background/Aim: Studies have reported that the expression of c-Met and PrPC improves tumor progression. However, not much is known about their relationship. We hypothesized that c-Met and PrPC interact with each other, and enhance cancer stem cell (CSC) characteristics. Materials and Methods: Magnetic activated cell sorting was used to examine the interaction between c-Met and PrPC. The effects of the interaction on downstream signals, stem cell marker expression, and sphere formation of colorectal cancer (CRC) cells were investigated. Results: We demonstrated the increased expression and binding levels of c-Met and PrPC in CRC cells compared to normal colon epithelial cells. We revealed that the c-Met and PrPC interaction induced the ERK activation and Oct4 upregulation. The inhibition of c-Met by crizotinib reduced ERK activation and Oct4 expression and suppressed CSC properties. Conclusion: c-Met and PrPC interact with each other, and targeting c-Met using crizotinib could be a powerful strategy for CRC therapy. | - |
dc.format.extent | 12 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | International Institute of Anticancer Research | - |
dc.title | PrPC Regulates the Cancer Stem Cell Properties via Interaction With c-Met in Colorectal Cancer Cells | - |
dc.type | Article | - |
dc.publisher.location | 그리이스 | - |
dc.identifier.doi | 10.21873/anticanres.15133 | - |
dc.identifier.scopusid | 2-s2.0-85109257596 | - |
dc.identifier.wosid | 000677481500001 | - |
dc.identifier.bibliographicCitation | Anticancer Research, v.41, no.7, pp 3459 - 3470 | - |
dc.citation.title | Anticancer Research | - |
dc.citation.volume | 41 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 3459 | - |
dc.citation.endPage | 3470 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.subject.keywordPlus | PRION PROTEIN | - |
dc.subject.keywordPlus | OVEREXPRESSION | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | INHIBITOR | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordAuthor | c-Met | - |
dc.subject.keywordAuthor | PrPC | - |
dc.subject.keywordAuthor | colorectal cancer | - |
dc.subject.keywordAuthor | crizotinib | - |
dc.subject.keywordAuthor | cancer stem cell | - |
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