Prognostic significance of bone marrow 2-[F-18]-fluoro-2-deoxy-D-glucose uptake in diffuse large B-cell lymphoma: relation to iliac crest biopsy results
DC Field | Value | Language |
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dc.contributor.author | Lim, C. H. | - |
dc.contributor.author | Hyun, S. H. | - |
dc.contributor.author | Cho, Y. S. | - |
dc.contributor.author | Choi, J. Y. | - |
dc.contributor.author | Lee, K-H | - |
dc.date.accessioned | 2021-09-10T05:45:44Z | - |
dc.date.available | 2021-09-10T05:45:44Z | - |
dc.date.issued | 2021-07 | - |
dc.identifier.issn | 0009-9260 | - |
dc.identifier.issn | 1365-229X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/18749 | - |
dc.description.abstract | AIM: To investigate the prognostic significance of bone marrow (BM) 2-[F-18]-fluoro-2-deoxy-D-glucose (FDG) uptake in relation to posterior iliac crest BM biopsy (BMB) results in diffuse large B-cell lymphoma (DLBCL). MATERIALS AND METHODS: Pretreatment integrated positron-emission tomography(PET)/computed tomography (CT) images of 512 DLBCL patients who underwent BMB and received rituximab combined with cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) chemotherapy were analysed retrospectively. BM uptake was assessed visually and by maximum standard uptake value (SUVmax). Associations with lymphoma-specific survival (LSS) were assessed using Kaplan-Meier and Cox regression analyses. RESULTS: FDG(+) BM was observed in 64 cases (41 focal, 12 heterogeneous, 11 diffuse). This finding distinguished iliac crest involvement (positive in 59 and negative in 453) with 89.6% accuracy (459/512) and 93.6% specificity (424/453). In BMB(+) patients, BM-to-liver SUVmax ratio >1.8 concurred perfectly with FDG(+) BM. During 52 months of follow-up, there were 156 lymphoma-related deaths. In the entire population, multivariate analysis revealed high International Prognostic Index (IPI; p<0.001), old age (p=0.003), bulky disease (p=0.011), BMB(+) (p=0.028), and FDG(+) BM (p=0.019) as independent predictors of worse LSS. In the BMB(+) subgroup, high National Comprehensive Cancer Network-revised IPI (NCCN-IPI; p=0.029) and FDG(+) BM (p=0.008) were significant independent predictors. Among BMB(+) patients with low to low-intermediate NCCN-IPI, FDG(+) BM was associated with significantly worse 2-year LSS (33.3% versus 100%; p=0.017). The same was true among those with high-intermediate NCCN-IPI (34.7% versus 76.9%.; p=0.026). CONCLUSION: Increased BM FDG in DLBCL is a predictor of worse LSS independent of BMB results and other prognostic variables including IPI/NCCN-IPI. (C) 2021 Published by Elsevier Ltd on behalf of The Royal College of Radiologists. | - |
dc.format.extent | 10 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | W. B. Saunders Co., Ltd. | - |
dc.title | Prognostic significance of bone marrow 2-[F-18]-fluoro-2-deoxy-D-glucose uptake in diffuse large B-cell lymphoma: relation to iliac crest biopsy results | - |
dc.type | Article | - |
dc.publisher.location | 영국 | - |
dc.identifier.doi | 10.1016/j.crad.2021.02.023 | - |
dc.identifier.scopusid | 2-s2.0-85103318133 | - |
dc.identifier.wosid | 000661280100018 | - |
dc.identifier.bibliographicCitation | Clinical Radiology, v.76, no.7, pp 19 - 28 | - |
dc.citation.title | Clinical Radiology | - |
dc.citation.volume | 76 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 19 | - |
dc.citation.endPage | 28 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.relation.journalWebOfScienceCategory | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.subject.keywordPlus | POSITRON-EMISSION-TOMOGRAPHY | - |
dc.subject.keywordPlus | CLINICAL-SIGNIFICANCE | - |
dc.subject.keywordPlus | FDG PET/CT | - |
dc.subject.keywordPlus | INVOLVEMENT | - |
dc.subject.keywordPlus | INFILTRATION | - |
dc.subject.keywordPlus | PITFALLS | - |
dc.subject.keywordPlus | PROVIDES | - |
dc.subject.keywordPlus | OUTCOMES | - |
dc.subject.keywordPlus | IPI | - |
dc.subject.keywordPlus | CT | - |
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