Mortality and Prognostic Factors of Nontuberculous Mycobacterial Infection in Korea: A Population-based Comparative Study
DC Field | Value | Language |
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dc.contributor.author | Lee, Hyewon | - |
dc.contributor.author | Myung, Woojae | - |
dc.contributor.author | Lee, Eun-Mi | - |
dc.contributor.author | Kim, Hyekyeong | - |
dc.contributor.author | Jhun, Byung Woo | - |
dc.date.accessioned | 2021-09-10T05:47:57Z | - |
dc.date.available | 2021-09-10T05:47:57Z | - |
dc.date.issued | 2021-05-15 | - |
dc.identifier.issn | 1058-4838 | - |
dc.identifier.issn | 1537-6591 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/18837 | - |
dc.description.abstract | Background. Population-based studies on the mortality burden of nontuberculous mycobacteria (NTM) infection are lacking. We compared the long-term mortality of NTM-infected patients with tuberculosis (TB)-patients and the general population, and investigated mortality-associated factors. Methods. We analyzed nationwide-data from the Korean National Health Insurance and Korea-Statistical Office between 2002 and 2017. NTM infection was identified using the International Classification of Disease, Tenth Revision code, with one-to-one matching to TB patients and general population controls. Results. A total of 530 401 individuals were analyzed, including 183 267 with NTM infections; 166 666 with TB; and 180 468 controls. The overall 6-, 10-, and 14-year cumulative survival probabilities in the NTM group were 86.3%, 80.8%, and 77.1%, respectively, which were significantly lower than those of the TB or control groups (log-rank P < .0001). In cases of NTM and TB coinfection, the overall 6-, 10-, and 14-year cumulative survival probabilities were 75.1%, 65.4%, and 57.0%, respectively. Multivariable analysis indicated that old age, male gender, province, and various respiratory or nonrespiratory comorbidities were significantly associated with mortality of NTM infection. The use of a macrolide (more than 1 year) negatively correlated with mortality of NTM infection (adjusted hazard ratio [aHR] 0.61, 95% confidence interval [CI] .53-.71), regardless of azithromycin (aHR 0.60, 95% CI .43-.85) or clarithromycin use (aHR 0.63, 95% CI .53-.75). Conclusions. NTM-infected patients had poor prognosis when compared to TB patients or the general population, especially for NTM and TB coinfection. NTM mortality was associated with certain demographic characteristics, but long-term use of macrolides may provide survival benefits. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | University of Chicago Press | - |
dc.title | Mortality and Prognostic Factors of Nontuberculous Mycobacterial Infection in Korea: A Population-based Comparative Study | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1093/cid/ciaa1381 | - |
dc.identifier.scopusid | 2-s2.0-85097508631 | - |
dc.identifier.wosid | 000661516500025 | - |
dc.identifier.bibliographicCitation | Clinical Infectious Diseases, v.72, no.10, pp E610 - E619 | - |
dc.citation.title | Clinical Infectious Diseases | - |
dc.citation.volume | 72 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | E610 | - |
dc.citation.endPage | E619 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalResearchArea | Infectious Diseases | - |
dc.relation.journalResearchArea | Microbiology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.relation.journalWebOfScienceCategory | Infectious Diseases | - |
dc.relation.journalWebOfScienceCategory | Microbiology | - |
dc.subject.keywordPlus | COMPLEX LUNG-DISEASE | - |
dc.subject.keywordPlus | TUBERCULOSIS TREATMENT | - |
dc.subject.keywordPlus | TREATMENT OUTCOMES | - |
dc.subject.keywordPlus | EPIDEMIOLOGY | - |
dc.subject.keywordPlus | PREVENTION | - |
dc.subject.keywordPlus | PREVALENCE | - |
dc.subject.keywordPlus | MACROLIDES | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordAuthor | nontuberculous mycobacteria | - |
dc.subject.keywordAuthor | tuberculosis | - |
dc.subject.keywordAuthor | mortality | - |
dc.subject.keywordAuthor | comorbidity | - |
dc.subject.keywordAuthor | macrolide | - |
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