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Mortality and Prognostic Factors of Nontuberculous Mycobacterial Infection in Korea: A Population-based Comparative Study

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dc.contributor.authorLee, Hyewon-
dc.contributor.authorMyung, Woojae-
dc.contributor.authorLee, Eun-Mi-
dc.contributor.authorKim, Hyekyeong-
dc.contributor.authorJhun, Byung Woo-
dc.date.accessioned2021-09-10T05:47:57Z-
dc.date.available2021-09-10T05:47:57Z-
dc.date.issued2021-05-15-
dc.identifier.issn1058-4838-
dc.identifier.issn1537-6591-
dc.identifier.urihttps://scholarworks.bwise.kr/sch/handle/2021.sw.sch/18837-
dc.description.abstractBackground. Population-based studies on the mortality burden of nontuberculous mycobacteria (NTM) infection are lacking. We compared the long-term mortality of NTM-infected patients with tuberculosis (TB)-patients and the general population, and investigated mortality-associated factors. Methods. We analyzed nationwide-data from the Korean National Health Insurance and Korea-Statistical Office between 2002 and 2017. NTM infection was identified using the International Classification of Disease, Tenth Revision code, with one-to-one matching to TB patients and general population controls. Results. A total of 530 401 individuals were analyzed, including 183 267 with NTM infections; 166 666 with TB; and 180 468 controls. The overall 6-, 10-, and 14-year cumulative survival probabilities in the NTM group were 86.3%, 80.8%, and 77.1%, respectively, which were significantly lower than those of the TB or control groups (log-rank P < .0001). In cases of NTM and TB coinfection, the overall 6-, 10-, and 14-year cumulative survival probabilities were 75.1%, 65.4%, and 57.0%, respectively. Multivariable analysis indicated that old age, male gender, province, and various respiratory or nonrespiratory comorbidities were significantly associated with mortality of NTM infection. The use of a macrolide (more than 1 year) negatively correlated with mortality of NTM infection (adjusted hazard ratio [aHR] 0.61, 95% confidence interval [CI] .53-.71), regardless of azithromycin (aHR 0.60, 95% CI .43-.85) or clarithromycin use (aHR 0.63, 95% CI .53-.75). Conclusions. NTM-infected patients had poor prognosis when compared to TB patients or the general population, especially for NTM and TB coinfection. NTM mortality was associated with certain demographic characteristics, but long-term use of macrolides may provide survival benefits.-
dc.language영어-
dc.language.isoENG-
dc.publisherUniversity of Chicago Press-
dc.titleMortality and Prognostic Factors of Nontuberculous Mycobacterial Infection in Korea: A Population-based Comparative Study-
dc.typeArticle-
dc.publisher.location미국-
dc.identifier.doi10.1093/cid/ciaa1381-
dc.identifier.scopusid2-s2.0-85097508631-
dc.identifier.wosid000661516500025-
dc.identifier.bibliographicCitationClinical Infectious Diseases, v.72, no.10, pp E610 - E619-
dc.citation.titleClinical Infectious Diseases-
dc.citation.volume72-
dc.citation.number10-
dc.citation.startPageE610-
dc.citation.endPageE619-
dc.type.docTypeArticle-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaImmunology-
dc.relation.journalResearchAreaInfectious Diseases-
dc.relation.journalResearchAreaMicrobiology-
dc.relation.journalWebOfScienceCategoryImmunology-
dc.relation.journalWebOfScienceCategoryInfectious Diseases-
dc.relation.journalWebOfScienceCategoryMicrobiology-
dc.subject.keywordPlusCOMPLEX LUNG-DISEASE-
dc.subject.keywordPlusTUBERCULOSIS TREATMENT-
dc.subject.keywordPlusTREATMENT OUTCOMES-
dc.subject.keywordPlusEPIDEMIOLOGY-
dc.subject.keywordPlusPREVENTION-
dc.subject.keywordPlusPREVALENCE-
dc.subject.keywordPlusMACROLIDES-
dc.subject.keywordPlusRISK-
dc.subject.keywordAuthornontuberculous mycobacteria-
dc.subject.keywordAuthortuberculosis-
dc.subject.keywordAuthormortality-
dc.subject.keywordAuthorcomorbidity-
dc.subject.keywordAuthormacrolide-
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