Astragaloside IV Suppresses Hepatic Proliferation in Regenerating Rat Liver after 70% Partial Hepatectomy via Down-Regulation of Cell Cycle Pathway and DNA Replication
DC Field | Value | Language |
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dc.contributor.author | Lee, Gyeong-Seok | - |
dc.contributor.author | Jeong, Hee-Yeon | - |
dc.contributor.author | Yang, Hyeon-Gung | - |
dc.contributor.author | Seo, Young-Ran | - |
dc.contributor.author | Jung, Eui-Gil | - |
dc.contributor.author | Lee, Yong-Seok | - |
dc.contributor.author | Nam, Kung-Woo | - |
dc.contributor.author | Kim, Wan-Jong | - |
dc.date.accessioned | 2021-09-10T05:48:49Z | - |
dc.date.available | 2021-09-10T05:48:49Z | - |
dc.date.issued | 2021-05 | - |
dc.identifier.issn | 1420-3049 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/18876 | - |
dc.description.abstract | Astragaloside IV (AS-IV) is one of the major bio-active ingredients of huang qi which is the dried root of Astragalus membranaceus (a traditional Chinese medicinal plant). The pharmacological effects of AS-IV, including anti-oxidative, anti-cancer, and anti-diabetic effects have been actively studied, however, the effects of AS-IV on liver regeneration have not yet been fully described. Thus, the aim of this study was to explore the effects of AS-IV on regenerating liver after 70% partial hepatectomy (PHx) in rats. Differentially expressed mRNAs, proliferative marker and growth factors were analyzed. AS-IV (10 mg/kg) was administrated orally 2 h before surgery. We found 20 core genes showed effects of AS-IV, many of which were involved with functions related to DNA replication during cell division. AS-IV down-regulates MAPK signaling, PI3/Akt signaling, and cell cycle pathway. Hepatocyte growth factor (HGF) and cyclin D1 expression were also decreased by AS-IV administration. Transforming growth factor beta 1 (TGF beta 1, growth regulation signal) was slightly increased. In short, AS-IV down-regulated proliferative signals and genes related to DNA replication. In conclusion, AS-IV showed anti-proliferative activity in regenerating liver tissue after 70% PHx. | - |
dc.format.extent | 13 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | - |
dc.title | Astragaloside IV Suppresses Hepatic Proliferation in Regenerating Rat Liver after 70% Partial Hepatectomy via Down-Regulation of Cell Cycle Pathway and DNA Replication | - |
dc.type | Article | - |
dc.publisher.location | 스위스 | - |
dc.identifier.doi | 10.3390/molecules26102895 | - |
dc.identifier.scopusid | 2-s2.0-85106565410 | - |
dc.identifier.wosid | 000655082800001 | - |
dc.identifier.bibliographicCitation | Molecules, v.26, no.10, pp 1 - 13 | - |
dc.citation.title | Molecules | - |
dc.citation.volume | 26 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 13 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.subject.keywordPlus | LIQUID-CHROMATOGRAPHY | - |
dc.subject.keywordPlus | TISSUE DISTRIBUTION | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | MEMBRANACEUS | - |
dc.subject.keywordPlus | PHARMACOKINETICS | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | PROTECTS | - |
dc.subject.keywordPlus | INVASION | - |
dc.subject.keywordPlus | HUANGQI | - |
dc.subject.keywordPlus | PLASMA | - |
dc.subject.keywordAuthor | astragaloside IV | - |
dc.subject.keywordAuthor | Astragalus membranaceus | - |
dc.subject.keywordAuthor | huang qi | - |
dc.subject.keywordAuthor | Astragali Radix | - |
dc.subject.keywordAuthor | liver | - |
dc.subject.keywordAuthor | liver regeneration | - |
dc.subject.keywordAuthor | 70% partial hepatectomy | - |
dc.subject.keywordAuthor | proliferation | - |
dc.subject.keywordAuthor | rat | - |
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