Antimicrobial activity of IDD-B40 against drug-resistant Mycobacterium tuberculosis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Islam, Md Imtiazul | - |
dc.contributor.author | Seo, Hoonhee | - |
dc.contributor.author | Kim, Sukyung | - |
dc.contributor.author | Sadu, Venkata S. | - |
dc.contributor.author | Lee, Kee-In | - |
dc.contributor.author | Song, Ho-Yeon | - |
dc.date.accessioned | 2021-09-10T06:25:13Z | - |
dc.date.available | 2021-09-10T06:25:13Z | - |
dc.date.issued | 2021-01-12 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/19011 | - |
dc.description.abstract | The emergence of multi-drug resistant (MDR) and extensively drug-resistant (XDR) Mycobacterium tuberculosis creates the urgency for new anti-tuberculosis drugs to improve the efficiency of current tuberculosis treatment. In the search for a new potential tuberculosis drug, we synthesized an isoindole based chemical library and screened a potential candidate with significant anti-tuberculosis activity. The compound named 2-hydroxy-4-(4-nitro-1,3-dioxoisoindolin-2-yl) benzoic acid (IDD-B40) showed strong activity against all the tested drug-susceptible and drug-resistant strains of M. tuberculosis, with the 50% minimum inhibitory concentrations (MIC50) of 0.39 mu g/ml both in culture broth and inside Raw 264.7 cells. Also, IDD-B40, in combination with rifampicin, exhibited a direct synergistic effect against both XDR and H37Rv M. tuberculosis. Besides, IDD-B40 showed a better post-antibiotic effect (PAE) than did some first-line drugs and showed no significant cytotoxicity to any cell line tested, with a selectivity index of >= 128. Although IDD-B40 showed a result similar to isoniazid in the preliminary mycolic acid inhibition assay, it did not exhibit any effect against other mycolic acid-producing nontuberculous mycobacterial strains (NTM), and different non-mycobacterial pathogenic strains, so further studies are required to confirm the mode of action of IDD-B40. Considering its results against M. tuberculosis, IDD-B40 is a potential anti-tuberculosis drug candidate. However, further studies are required to evaluate its potential in vivo effect and therapeutic potential. | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Nature Publishing Group | - |
dc.title | Antimicrobial activity of IDD-B40 against drug-resistant Mycobacterium tuberculosis | - |
dc.type | Article | - |
dc.publisher.location | 영국 | - |
dc.identifier.doi | 10.1038/s41598-020-80227-y | - |
dc.identifier.scopusid | 2-s2.0-85099383150 | - |
dc.identifier.wosid | 000621920400088 | - |
dc.identifier.bibliographicCitation | Scientific Reports, v.11, no.1, pp 1 - 9 | - |
dc.citation.title | Scientific Reports | - |
dc.citation.volume | 11 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 9 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | IN-VITRO ACTIVITY | - |
dc.subject.keywordPlus | DERIVATIVES | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | ACID | - |
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