A Clinical Trial to Evaluate the Efficacy of alpha-Viniferin in Staphylococcus aureus - Specific Decolonization without Depleting the Normal Microbiota of Nares
DC Field | Value | Language |
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dc.contributor.author | Rahim, Md Abdur | - |
dc.contributor.author | Seo, Hoonhee | - |
dc.contributor.author | Kim, Sukyung | - |
dc.contributor.author | Jeong, Yoon Kyoung | - |
dc.contributor.author | Tajdozian, Hanieh | - |
dc.contributor.author | Kim, Mijung | - |
dc.contributor.author | Lee, Saebim | - |
dc.contributor.author | Song, Ho-Yeon | - |
dc.date.accessioned | 2021-09-10T06:27:25Z | - |
dc.date.available | 2021-09-10T06:27:25Z | - |
dc.date.issued | 2021-03 | - |
dc.identifier.issn | 1733-1331 | - |
dc.identifier.issn | 2544-4646 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/19098 | - |
dc.description.abstract | Staphylococcus aureus is currently a significant multidrug-resistant bacterium, causing severe healthcare-associated and community-acquired infections worldwide. The current antibiotic regimen against this pathogen is becoming ineffective due to resistance, in addition, they disrupt the normal microbiota. It highlights the urgent need for a pathogen-specific drug with high antibacterial efficacy against S. aureus. alpha-Viniferin, a bioactive phytochemical compound, has been reported to have excellent anti-Staphylococcus efficacy as a topical agent. However, so far, there were no clinical trials that have been conducted to elucidate its efficacy. The present study aimed to investigate the antibacterial efficacy of alpha-viniferin against S. aureus in a ten-day clinical trial. Based on the results, alpha-viniferin showed 50% minimum inhibitory concentrations (MIC50 values) of 7.8 mu g/ml in culture broth medium. alpha-Viniferin was administered in the nares three times a day for ten days using a sterile cotton swab stick. Nasal swab specimens were collected before (0 days) and after finishing the trial (10th day), and then analyzed. In the culture and RT-PCR-based analysis, S. ureus was reduced significantly: 0.01. In addition, 16S ribosomal RNA-based amplicon sequencing analysis showed that S. aureus reduced from 51.03% to 23.99% at the genus level. RNA-seq analysis was also done to gain insights into molecular mechanisms of alpha-viniferin against S. aureus, which revealed that some gene groups were reduced in 5-fold FC cutoff at two times MIC conditions. The study results demonstrate alpha-viniferin as a potential S. aureus-specific drug candidate. | - |
dc.format.extent | 14 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Polskie Towarzystwo Mikrobiologow/Polish Society of Microbiologists | - |
dc.title | A Clinical Trial to Evaluate the Efficacy of alpha-Viniferin in Staphylococcus aureus - Specific Decolonization without Depleting the Normal Microbiota of Nares | - |
dc.type | Article | - |
dc.publisher.location | 폴란드 | - |
dc.identifier.doi | 10.33073/pjm-2021-011 | - |
dc.identifier.scopusid | 2-s2.0-85103922672 | - |
dc.identifier.wosid | 000631127100012 | - |
dc.identifier.bibliographicCitation | Polish Journal of Microbiology, v.70, no.1, pp 117 - 130 | - |
dc.citation.title | Polish Journal of Microbiology | - |
dc.citation.volume | 70 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 117 | - |
dc.citation.endPage | 130 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Microbiology | - |
dc.relation.journalWebOfScienceCategory | Microbiology | - |
dc.subject.keywordPlus | VANCOMYCIN | - |
dc.subject.keywordAuthor | alpha-viniferin | - |
dc.subject.keywordAuthor | clinical trial | - |
dc.subject.keywordAuthor | MRSA | - |
dc.subject.keywordAuthor | PCR | - |
dc.subject.keywordAuthor | 16S rRNA amplicon sequencing analysis | - |
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