Atypical Antipsychotics Augmentation in Patients with Depressive Disorder and Risk of Subsequent Dementia: A Nationwide Population-Based Cohort Study
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Jaehyun | - |
dc.contributor.author | Ha, Tae Hyon | - |
dc.contributor.author | Kim, Kiwon | - |
dc.contributor.author | Lee, Eun-Mi | - |
dc.contributor.author | Kim, Hyekyeong | - |
dc.contributor.author | Kim, Doh Kwan | - |
dc.contributor.author | Won, Hong-Hee | - |
dc.contributor.author | Lewis, Matthew | - |
dc.contributor.author | Lee, Hyewon | - |
dc.contributor.author | Myung, Woojae | - |
dc.date.accessioned | 2021-09-10T06:27:27Z | - |
dc.date.available | 2021-09-10T06:27:27Z | - |
dc.date.issued | 2021 | - |
dc.identifier.issn | 1387-2877 | - |
dc.identifier.issn | 1875-8908 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/19100 | - |
dc.description.abstract | Background: While atypical antipsychotic medications are widely used for treating depressive disorders, their long-term effects on the risk of subsequent dementia have not been studied adequately. Objective: To investigate whether the risk of dementia differs according to the use of atypical antipsychotic drugs, and compare the effects of antipsychotic agents on dementia risk in individuals with late-life depressive disorders. Methods: A nationwide population-based retrospective cohort study was conducted using data from the National Health Insurance Service-Senior Cohort of South Korea. Atypical antipsychotic dosages were standardized using a defined daily dose, and the cumulative dosage was calculated. Participants were observed from January 2008 to December 2015. Cox proportional hazard regression analysis was used to estimate the hazard ratios. Results: The cohort included 43,788 elderly adults with depressive disorders: 9,901 participants (22.6%) were diagnosed with dementia. Findings showed that atypical antipsychotics were prescribed to 1,967 participants (4.5%). Compared with non-users, users of atypical antipsychotics experienced a significantly higher risk for dementia with an adjusted hazard ratio (aHR) of 1.541 (95% confidence interval [CI], 1.415-1.678). A cumulative dose-response relationship was observed (test for trend, p < 0.0001). Among atypical antipsychotics, risperidone displayed the highest risk for dementia (aHR 1.767, [95% CI, 1.555-2.009]). Conclusion: In this study of elderly individuals with depressive disorders, atypical antipsychotic use was associated with a significantly higher risk of subsequent dementia. Healthcare professionals should be aware of this potential long-term risk. A limitation that should be mentioned is that we could not exclude patients with bipolar depression. | - |
dc.format.extent | 11 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | IOS Press | - |
dc.title | Atypical Antipsychotics Augmentation in Patients with Depressive Disorder and Risk of Subsequent Dementia: A Nationwide Population-Based Cohort Study | - |
dc.type | Article | - |
dc.publisher.location | 네델란드 | - |
dc.identifier.doi | 10.3233/JAD-200994 | - |
dc.identifier.scopusid | 2-s2.0-85102965325 | - |
dc.identifier.wosid | 000627617100015 | - |
dc.identifier.bibliographicCitation | Journal of Alzheimer's Disease, v.80, no.1, pp 197 - 207 | - |
dc.citation.title | Journal of Alzheimer's Disease | - |
dc.citation.volume | 80 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 197 | - |
dc.citation.endPage | 207 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.subject.keywordPlus | ALZHEIMERS-DISEASE | - |
dc.subject.keywordPlus | ELDERLY-PATIENTS | - |
dc.subject.keywordPlus | COGNITIVE DECLINE | - |
dc.subject.keywordPlus | ISCHEMIC-STROKE | - |
dc.subject.keywordPlus | BIPOLAR | - |
dc.subject.keywordPlus | MEDICATION | - |
dc.subject.keywordPlus | LITHIUM | - |
dc.subject.keywordPlus | SCHIZOPHRENIA | - |
dc.subject.keywordPlus | RISPERIDONE | - |
dc.subject.keywordPlus | SEVERITY | - |
dc.subject.keywordAuthor | Antipsychotic agents | - |
dc.subject.keywordAuthor | dementia | - |
dc.subject.keywordAuthor | depression | - |
dc.subject.keywordAuthor | mood disorders | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(31538) 22, Soonchunhyang-ro, Asan-si, Chungcheongnam-do, Republic of Korea+82-41-530-1114
COPYRIGHT 2021 by SOONCHUNHYANG UNIVERSITY ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.