어루러기에서 경구 아졸계 항진균제의 치료 효과 비교: 체계적 문헌고찰 및 메타분석Comparison of the Efficacy of Oral Azoles in Pityriasis Versicolor: A Systematic Review and Meta-Analysis
- Other Titles
- Comparison of the Efficacy of Oral Azoles in Pityriasis Versicolor: A Systematic Review and Meta-Analysis
- Authors
- 권륭; 이설희; 박영립; 이상훈
- Issue Date
- 2021
- Publisher
- 대한피부과학회
- Keywords
- Antifulgal agents; Azoles; Fluconazole; Itraconazole; Ketoconazole; Tinea versicolor
- Citation
- 대한피부과학회지, v.59, no.5, pp.370 - 378
- Journal Title
- 대한피부과학회지
- Volume
- 59
- Number
- 5
- Start Page
- 370
- End Page
- 378
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/19173
- ISSN
- 0494-4739
- Abstract
- Background: In pityriasis versicolor, systemic antifungal agents may be indicated for widespread or refractory lesions rather than topical treatment. Oral ketoconazole is an effective treatment for pityriasis versicolor. To our knowledge, this is the first meta-analysis to compare antifungal agents one-to-one.
Objective: To compare the effectiveness of oral azole antifungal agents (fluconazole, itraconazole, and ketoconazole) one-to-one in pityriasis versicolor.
Methods: A computerized search was performed in different databases, including PubMed, Cochrane, EMBASE, OVID Medline, KoreaMed, KISS, and MedRIC. Seven randomized controlled trials were included. Further, statistical analyses of the extracted outcome data from the studies were performed using Rex Software (ver. 3.0.1).
Results: A total of 1,828 records were identified. The results of the meta-analysis including seven studies revealed no significant differences in the mycological cure rates between fluconazole and ketoconazole (risk ratio [RR]: 1.01, 95% confidence interval [CI]: 0.93∼1.09, p=0.8246), fluconazole and itraconazole (RR: 1.14, 95% CI: 0.81∼1.60, p=0.4512), and ketoconazole and itraconazole (RR: 1.07, 95% CI: 0.96∼1.20, p=0.2265).
Conclusion: There was no superiority in the therapeutic effect of any drug among the oral azole antifungals used in pityriasis versicolor.
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