지역사회 거주 노인의 인지기능과 우울증상 사이의 상관성 분석

Abstract

Objective: The aim of this study was to reveal the association between the depressive symptom and cognitive function of participants with normal cognitive function, mild cognitive impairment (MCI), and dementia in a large-scale community elderly cohort. Methods: A total of 6,338 elderly participants who participated in the Korean Longitudinal Study on Cognitive Aging and Dementia (KLOSCAD) from November 2010 to October 2012 were evaluated through cross-sectional analysis. Cognitive evaluation was conducted with Korean Version of Mini Mental Status Exam for Dementia Screening (MMSE-DS) and Consortium to Establish a Registry for Alzheimer’s Disease Assessment Packet (CERAD) neuropsychological tests, and depressive symptoms were evaluated with Revised Korean Version of the Geriatric Depression Scale (GDS-KR). Results: 4,352 normal cognitive elderly participants, 1,748 MCI and 238 dementia participants were enrolled in the study. Correlation analysis showed a significant negative correlation between MMSE-DS and GDS-KR in the normal elderly group and participants with MCI, but not in dementia participants. This was the same in the correlation between CERAD-TS (total score) and GDSKR score. Conclusion: This study found that worse cognitive function in the community cohort worsened depressive symptoms in groups with normal and MCI, but no significant correlation was observed in patients with dementia.