Sensitization profile to sawtooth oak component allergens and their clinical implications
DC Field | Value | Language |
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dc.contributor.author | Jeong, Kyoung Yong | - |
dc.contributor.author | Lee, Jongsun | - |
dc.contributor.author | Sang, Min Kyu | - |
dc.contributor.author | Lee, Yong Seok | - |
dc.contributor.author | Park, Kyung Hee | - |
dc.contributor.author | Lee, Jae-Hyun | - |
dc.contributor.author | Park, Jung-Won | - |
dc.date.accessioned | 2021-09-10T06:44:56Z | - |
dc.date.available | 2021-09-10T06:44:56Z | - |
dc.date.issued | 2021-07 | - |
dc.identifier.issn | 0887-8013 | - |
dc.identifier.issn | 1098-2825 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/19311 | - |
dc.description.abstract | Objective The component allergens from sawtooth oak, which is a main cause of tree pollinosis in Korea, have not been extensively characterized except Que ac 1. This study was undertaken to characterize the allergenic components from sawtooth oak pollen and investigate the diagnostic values of each component allergen. Methods Transcriptomic analysis was performed to identify the birch pollen allergen homologues from sawtooth oak pollen. Recombinant Que ac 1, 2, 3, 6, 7, and 8 were produced in an E. coli expression system. IgE reactivity to each allergen was examined by ImmunoCAP and ELISA using the sera of 50 Korean tree pollinosis patients. Results Six birch pollen allergen homologues were identified using transcriptome analysis, as follows: Que ac 1 (54.8% identity to Bet v 1), Que ac 2 (79.7% to Bet v 2), Que ac 3 (24.9% to Bet v 3), 6 (71.3% to Bet v 6), Que ac 7 (80.9% to Bet v 7), and Que ac 8 (78.9% to Bet v 8). Que ac 1 sIgE was the most frequently recognized (84.0%), followed by Que ac 2 (12.0%), Que ac 3 (6.0%), and three other allergens (2.0% each). Que ac 1 was a dominant allergen affecting 83.7% of patients suffering from allergic rhinoconjunctivitis, and 92.9% of pollen food allergy syndrome patients. Conclusion Five novel IgE reactive components of sawtooth oak were characterized using transcriptome analysis. Que ac 1 is the single most important component allergen of sawtooth oak pollen. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | John Wiley & Sons Inc. | - |
dc.title | Sensitization profile to sawtooth oak component allergens and their clinical implications | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1002/jcla.23825 | - |
dc.identifier.scopusid | 2-s2.0-85105795830 | - |
dc.identifier.wosid | 000651366200001 | - |
dc.identifier.bibliographicCitation | Journal of Clinical Laboratory Analysis, v.35, no.7 | - |
dc.citation.title | Journal of Clinical Laboratory Analysis | - |
dc.citation.volume | 35 | - |
dc.citation.number | 7 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Medical Laboratory Technology | - |
dc.relation.journalWebOfScienceCategory | Medical Laboratory Technology | - |
dc.subject.keywordPlus | BIRCH POLLEN ALLERGEN | - |
dc.subject.keywordPlus | MAJOR ALLERGEN | - |
dc.subject.keywordPlus | REACTIVITY | - |
dc.subject.keywordPlus | BINDING | - |
dc.subject.keywordAuthor | allergen | - |
dc.subject.keywordAuthor | oak | - |
dc.subject.keywordAuthor | pollinosis | - |
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