Diagnostic challenges of indolent peripheral T cell lymphoma A case report and literature review
DC Field | Value | Language |
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dc.contributor.author | Lee, Jisoo | - |
dc.contributor.author | Park, Kyeoungseo | - |
dc.contributor.author | Kim, Kyoung Ha | - |
dc.contributor.author | Bang, Hae In | - |
dc.contributor.author | Yoon, Seug Yun | - |
dc.contributor.author | Choi, In Ho | - |
dc.date.accessioned | 2021-09-10T06:47:46Z | - |
dc.date.available | 2021-09-10T06:47:46Z | - |
dc.date.issued | 2020-10 | - |
dc.identifier.issn | 0025-7974 | - |
dc.identifier.issn | 1536-5964 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/19422 | - |
dc.description.abstract | Introduction: Peripheral T cell lymphoma, not otherwise specified (PTCL-NOS) is a heterogeneous group of mature T cell lymphomas which do not correspond to any specific subtype of mature T-cell lymphoma in current classifications. Some researchers have suggested that PTCL with low Ki-67 labeling index should be classified as indolent PTCL Patient concerns: A 58-year old man diagnosed with alcoholic fatty liver 3 months prior complained of tenesmus and abdominal distension. Colonoscopy of the small and large intestines revealed multiple polyps, which were histologically diagnosed as lymphoid hyperplasia. One month later, he re-visited with a weight loss of 3 to 4 kg over 2 months. Radiologic examination revealed numerous small, homogenous, hypovascular lymph node enlargement in the para-aortic, mesenteric, and both inguinal areas, suggesting malignant lymphoma. Diagnosis: Laparoscopic biopsy of an omental lymph node was performed, which was histologically confirmed as PTCL-NOS. Interventions: The patient was administered 3 cycles of cyclophosphamide, doxorubicin, vincristine, and prednisone, but his general condition did not improve. Therefore, treatment was changed to ifosfamide, carboplatin, and etoposide -dexamethasone (4 cycles) followed by allogeneic stem cell transplantation. Outcome: Even after allogeneic stem cell transplantation, fluorodeoxyglucose uptake in his abdominal lymph nodes and small bowel in positron emission tomography- computed tomography persisted at a Deauville score of 4. The patient has been followed-up for 2 years without progression. Conclusion: These indolent PTCLs histologically show diffuse infiltrated small lymphoid cells with low KI-67 labeling index and have a relatively good prognosis, although the epidemiology and pathogenesis are not fully elucidated. We report a case of indolent PTCL with cytogenetic abnormalities and poor response to chemotherapy, along with a brief review of the literature. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Lippincott Williams & Wilkins Ltd. | - |
dc.title | Diagnostic challenges of indolent peripheral T cell lymphoma A case report and literature review | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1097/MD.0000000000022657 | - |
dc.identifier.scopusid | 2-s2.0-85094219775 | - |
dc.identifier.wosid | 000589394700039 | - |
dc.identifier.bibliographicCitation | Medicine, v.99, no.42, pp 1 - 8 | - |
dc.citation.title | Medicine | - |
dc.citation.volume | 99 | - |
dc.citation.number | 42 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 8 | - |
dc.type.docType | Review | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordAuthor | indolent T cell lymphoma | - |
dc.subject.keywordAuthor | indolent T-cell lymphoproliferative disease of gastrointestinal tracts | - |
dc.subject.keywordAuthor | low grade T cell lymphoma | - |
dc.subject.keywordAuthor | peripheral T cell lymphoma | - |
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