Altered Regional Cerebral Blood Perfusion in Mild Cognitive Impairment Patients with Dizziness
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Na, Seunghee | - |
dc.contributor.author | Im, Jooyeon Jamie | - |
dc.contributor.author | Jeong, Hyeonseok | - |
dc.contributor.author | Lee, Eek-Sung | - |
dc.contributor.author | Lee, Tae-Kyeong | - |
dc.contributor.author | Chung, Yong-An | - |
dc.contributor.author | Song, In-Uk | - |
dc.date.accessioned | 2021-09-10T06:48:01Z | - |
dc.date.available | 2021-09-10T06:48:01Z | - |
dc.date.issued | 2020-10 | - |
dc.identifier.issn | 2075-4418 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/19433 | - |
dc.description.abstract | Dizziness is a common symptom among the general population, especially in the elderly. Previous studies have reported that dizziness may be associated with various cognitive functions including memory impairment. However, few studies have investigated the neural correlates of dizziness in patients with cognitive impairment. The aim of this study was to examine regional cerebral blood flow (rCBF) in mild cognitive impairment (MCI) patients with or without dizziness using single photon emission computed tomography (SPECT). A total of 50 patients with MCI were recruited. All participants underwent technetium-99m ethyl cysteinate dimer brain SPECT and a neuropsychological battery and completed the Dizziness Handicap Inventory (DHI). Participants were divided into a dizziness group (DHI >= 1, n = 18) and a non-dizziness group (DHI = 0, n = 32). Voxel wise differences in rCBF between the groups were estimated. SPECT analysis revealed decreased rCBF in the left superior temporal gyrus, left lateral orbital gyrus, and right middle frontal gyrus in the dizziness group compared with the non-dizziness group (p < 0.005). No significant clusters of increased rCBF were observed in the dizziness group compared with the non-dizziness group. Results of the neuropsychological tests showed a significant difference in Controlled Oral Word Association Test performance between MCI patients with and without dizziness. In conclusion, MCI patients with dizziness showed multifocal frontal and left temporal hypoperfusion compared with patients without dizziness. Our results suggest that hypoperfusion in the frontal and temporal cortices might be reflecting the negative impact of dizziness in MCI patients. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | MDPI AG | - |
dc.title | Altered Regional Cerebral Blood Perfusion in Mild Cognitive Impairment Patients with Dizziness | - |
dc.type | Article | - |
dc.publisher.location | 스위스 | - |
dc.identifier.doi | 10.3390/diagnostics10100777 | - |
dc.identifier.scopusid | 2-s2.0-85092239253 | - |
dc.identifier.wosid | 000585280400001 | - |
dc.identifier.bibliographicCitation | Diagnostics, v.10, no.10 | - |
dc.citation.title | Diagnostics | - |
dc.citation.volume | 10 | - |
dc.citation.number | 10 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | VESTIBULAR SYSTEM | - |
dc.subject.keywordPlus | DEFICITS | - |
dc.subject.keywordPlus | ATROPHY | - |
dc.subject.keywordPlus | CORTEX | - |
dc.subject.keywordPlus | MEMORY | - |
dc.subject.keywordPlus | GYRUS | - |
dc.subject.keywordPlus | AGE | - |
dc.subject.keywordAuthor | dizziness | - |
dc.subject.keywordAuthor | mild cognitive impairment | - |
dc.subject.keywordAuthor | single photon emission computed tomography | - |
dc.subject.keywordAuthor | brain perfusion | - |
dc.subject.keywordAuthor | regional cerebral blood flow | - |
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