C3d-Positive Preformed DSAs Tend to Persist and Result in a Higher Risk of AMR after Kidney Transplants
DC Field | Value | Language |
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dc.contributor.author | Choi, Sooin | - |
dc.contributor.author | Lee, Kyo Won | - |
dc.contributor.author | Park, Jae Berm | - |
dc.contributor.author | Kim, Kyunga | - |
dc.contributor.author | Jang, Hye-Ryeon | - |
dc.contributor.author | Huh, Wooseong | - |
dc.contributor.author | Kang, Eun Suk | - |
dc.date.accessioned | 2021-09-10T07:24:35Z | - |
dc.date.available | 2021-09-10T07:24:35Z | - |
dc.date.issued | 2020-02 | - |
dc.identifier.issn | 2077-0383 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/19586 | - |
dc.description.abstract | C3d-binding assays have been introduced as methods for the prediction of the presence of complement-binding functional antibodies; however, the prognostic value of C3d-positive preformed donor-specific antibodies (pDSAs) has not been fully evaluated. In this study, we performed a retrospective investigation of the association of pDSAs and their C3d-binding capacity with one-year clinical outcomes. pDSAs were defined as donor-specific antibodies (DSAs) that were produced before kidney transplants (KTs) (pre-pDSAs) or within the first four weeks after KTs, owing to rebound immune response (post-pDSAs). Of 455 adult KT recipients, pre-pDSAs and post-pDSAs were found in 56 (12.3%) and 56 (12.3%) recipients, respectively, and C3d-positive post-pDSAs were found in 13 recipients (2.9%) in total. Approximately half of the C3d-negative pre-pDSAs (37/73, 50.7%) disappeared after transplantation; however, all C3d-positive pre-pDSAs (8/8, 100%) persisted after transplantation despite desensitization (p = 0.008). C3d-positive pDSAs were significantly associated with a higher incidence and risk of AMR (p < 0.001, OR 94.467-188.934). Identification of the C3d-binding activity of pDSAs before and early after KT is important for predicting the persistence of pDSAs and the risk of AMR induced by the presence of pDSAs. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | MDPI AG | - |
dc.title | C3d-Positive Preformed DSAs Tend to Persist and Result in a Higher Risk of AMR after Kidney Transplants | - |
dc.type | Article | - |
dc.publisher.location | 스위스 | - |
dc.identifier.doi | 10.3390/jcm9020375 | - |
dc.identifier.scopusid | 2-s2.0-85114280640 | - |
dc.identifier.wosid | 000518823000087 | - |
dc.identifier.bibliographicCitation | Journal of Clinical Medicine, v.9, no.2 | - |
dc.citation.title | Journal of Clinical Medicine | - |
dc.citation.volume | 9 | - |
dc.citation.number | 2 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | DONOR-SPECIFIC ANTIBODIES | - |
dc.subject.keywordPlus | ANTI-HLA ANTIBODIES | - |
dc.subject.keywordPlus | MEDIATED REJECTION | - |
dc.subject.keywordPlus | RECIPIENTS | - |
dc.subject.keywordPlus | IMPACT | - |
dc.subject.keywordAuthor | kidney transplant (KT) | - |
dc.subject.keywordAuthor | donor-specific antibodies (DSA) | - |
dc.subject.keywordAuthor | C3d-binding assay | - |
dc.subject.keywordAuthor | antibody-mediated rejection (AMR) | - |
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