Clinical correlates associated with the long-term response of bipolar disorder patients to lithium, valproate or lamotrigine: A retrospective study
DC Field | Value | Language |
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dc.contributor.author | Woo, Young Sup | - |
dc.contributor.author | Yoon, Bo-Hyun | - |
dc.contributor.author | Song, Jye-Heon | - |
dc.contributor.author | Seo, Jeong Seok | - |
dc.contributor.author | Nam, Beomwoo | - |
dc.contributor.author | Lee, Kwanghun | - |
dc.contributor.author | Lee, Jonghun | - |
dc.contributor.author | Jung, Young-Eun | - |
dc.contributor.author | Kim, Moon-Doo | - |
dc.contributor.author | Lee, Jung Goo | - |
dc.contributor.author | Wang, Sheng-Min | - |
dc.contributor.author | Kwon, Young-Joon | - |
dc.contributor.author | Bahk, Won-Myong | - |
dc.date.accessioned | 2021-09-10T07:24:43Z | - |
dc.date.available | 2021-09-10T07:24:43Z | - |
dc.date.issued | 2020-01-10 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/19591 | - |
dc.description.abstract | Background Although mood stabilizers such as lithium (LIT), valproate (VAL), and lamotrigine (LMT) appear to be efficacious treatments for bipolar disorder (BD) in research settings, the long-term response to these mood stabilizers in clinical practice is highly variable among individuals. Thus, the present study examined the characteristics associated with good or insufficient responses to long-term treatment with LIT, VAL, or LMT for BD. Methods This study retrospectively analyzed the medical records of patients who visited an outpatient clinic with a diagnosis of BD I or II. Data from patients who were treated with one of three mood stabilizing medications (LIT, VAL, or LMT) for more than 6 months were selected, and the long-term treatment responses were evaluated using the Alda scale. For the purposes of this study, two response categories were formed: insufficient response (ISR), including non-response or poor response (Alda total score. 6), and good response (GR; Alda total score. 7). Results Of the 645 patients included in the present study, 172 were prescribed LIT, 320 were prescribed VAL, and 153 were prescribed LMT for at least 6 months. A binary logistic regression analysis revealed that a diagnosis of BD II (odds ratio [OR], 8.868; 95% confidence interval [CI], 1.123-70.046; p = 0.038), comorbid alcohol/substance use disorder (OR, 4.238; 95% CI, 1.154-15.566; p = 0.030), and a history of mixed episodes (OR, 4.363; 95% CI, 1.191-15.985; p = 0.026) were significant predictors of LIT-ISR. Additionally, a depressive-predominant polarity significantly predicted LMT-GR (OR, 8.586; 95% CI, 2.767-26.644; p < 0.001). Conclusion The present findings demonstrated that patients with a diagnosis of BD II, a comorbid alcohol/substance problem, or a history of mixed episodes were not likely to respond to LIT treatment. Additionally, LMT might be a better treatment choice for patients with a depressive-predominant polarity. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Public Library of Science | - |
dc.title | Clinical correlates associated with the long-term response of bipolar disorder patients to lithium, valproate or lamotrigine: A retrospective study | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1371/journal.pone.0227217 | - |
dc.identifier.scopusid | 2-s2.0-85077765806 | - |
dc.identifier.wosid | 000534350000057 | - |
dc.identifier.bibliographicCitation | PLoS ONE, v.15, no.1 | - |
dc.citation.title | PLoS ONE | - |
dc.citation.volume | 15 | - |
dc.citation.number | 1 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | KOREAN MEDICATION ALGORITHM | - |
dc.subject.keywordPlus | PREDOMINANT POLARITY | - |
dc.subject.keywordPlus | PROPHYLACTIC LITHIUM | - |
dc.subject.keywordPlus | MAINTENANCE | - |
dc.subject.keywordPlus | DIVALPROEX | - |
dc.subject.keywordPlus | EFFICACY | - |
dc.subject.keywordPlus | CARBAMAZEPINE | - |
dc.subject.keywordPlus | PREDICTORS | - |
dc.subject.keywordPlus | PREVENTION | - |
dc.subject.keywordPlus | PLACEBO | - |
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