Adipose Tissue Dendritic Cells: Critical Regulators of Obesity-Induced Inflammation and Insulin Resistance
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Soedono, Shindy | - |
dc.contributor.author | Cho, Kae Won | - |
dc.date.accessioned | 2021-10-05T04:42:38Z | - |
dc.date.available | 2021-10-05T04:42:38Z | - |
dc.date.issued | 2021-08 | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.issn | 1422-0067 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/19855 | - |
dc.description.abstract | Chronic inflammation of the adipose tissue (AT) is a critical component of obesity-induced insulin resistance and type 2 diabetes. Adipose tissue immune cells, including AT macrophages (ATMs), AT dendritic cells (ATDCs), and T cells, are dynamically regulated by obesity and participate in obesity-induced inflammation. Among AT resident immune cells, ATDCs are master immune regulators and engage in crosstalk with various immune cells to initiate and regulate immune responses. However, due to confounding markers and lack of animal models, their exact role and contribution to the initiation and maintenance of AT inflammation and insulin resistance have not been clearly elucidated. This paper reviews the current understanding of ATDCs and their role in obesity-induced AT inflammation. We also provide the potential mechanisms by which ATDCs regulate AT inflammation and insulin resistance in obesity. Finally, this review offers perspectives on ways to better dissect the distinct functions and contributions of ATDCs to obesity. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | - |
dc.title | Adipose Tissue Dendritic Cells: Critical Regulators of Obesity-Induced Inflammation and Insulin Resistance | - |
dc.type | Article | - |
dc.publisher.location | 스위스 | - |
dc.identifier.doi | 10.3390/ijms22168666 | - |
dc.identifier.scopusid | 2-s2.0-85112282022 | - |
dc.identifier.wosid | 000689193400001 | - |
dc.identifier.bibliographicCitation | International Journal of Molecular Sciences, v.22, no.16 | - |
dc.citation.title | International Journal of Molecular Sciences | - |
dc.citation.volume | 22 | - |
dc.citation.number | 16 | - |
dc.type.docType | Review | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.subject.keywordPlus | PERIPHERAL LYMPHOID ORGANS | - |
dc.subject.keywordPlus | CD4(+) T-CELLS | - |
dc.subject.keywordPlus | DIET-INDUCED OBESITY | - |
dc.subject.keywordPlus | MACROPHAGE INFILTRATION | - |
dc.subject.keywordPlus | SYSTEMIC INFLAMMATION | - |
dc.subject.keywordPlus | METABOLIC SYNDROME | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | CD8(+) | - |
dc.subject.keywordAuthor | obesity | - |
dc.subject.keywordAuthor | adipose tissue | - |
dc.subject.keywordAuthor | dendritic cells | - |
dc.subject.keywordAuthor | insulin resistance | - |
dc.subject.keywordAuthor | inflammation | - |
dc.subject.keywordAuthor | antigen presentation | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(31538) 22, Soonchunhyang-ro, Asan-si, Chungcheongnam-do, Republic of Korea+82-41-530-1114
COPYRIGHT 2021 by SOONCHUNHYANG UNIVERSITY ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.