Tetrahydrocurcumin Ameliorates Kidney Injury and High Systolic Blood Pressure in High-Fat Diet-Induced Type 2 Diabetic Mice
DC Field | Value | Language |
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dc.contributor.author | Sangartit, Weerapon | - |
dc.contributor.author | Ha, Kyung Bong | - |
dc.contributor.author | Lee, Eun Soo | - |
dc.contributor.author | Kim, Hong Min | - |
dc.contributor.author | Kukongviriyapan, Upa | - |
dc.contributor.author | Lee, Eun Young | - |
dc.contributor.author | Chung, Choon Hee | - |
dc.date.accessioned | 2021-10-05T04:42:52Z | - |
dc.date.available | 2021-10-05T04:42:52Z | - |
dc.date.issued | 2021-08-01 | - |
dc.identifier.issn | 2093-596X | - |
dc.identifier.issn | 2093-5978 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/19866 | - |
dc.description.abstract | Background: Activation of the intrarenal renin-angiotensin system (RAS) is implicated in the pathogenesis of kidney injury and hypertension. We aimed to investigate the protective effect of tetrahydrocurcumin (THU) on intrarenal RAS expression, kidney injury, and systolic blood pressure (SBP) in high-fat diet (HFD)-induced type 2 diabetic mice. Methods: Eight-week-old male mice were fed a regular diet (RD) or HFD for 12 weeks, and THU (50 or 100 mg/kg/day) was intragastrically administered with HFD. Physiological and metabolic changes were monitored and the expression of RAS components and markers of kidney injury were assessed. Results: HFD-fed mice exhibited hyperglycemia, insulin resistance, and dyslipidemia compared to those in the RD group (P<0.05). Kidney injury in these mice was indicated by an increase in the ratio of albumin to creatinine, glomerular hypertrophy, and the effacement of podocyte foot processes. Expression of intrarenal angiotensin-converting enzyme, angiotensin II type I receptor, nicotinamide adenine dinucleotide phosphate (NADPH) oxidase-4, and monocyte chemoattractant protein-1 was also markedly increased in HFD-fed mice. HFD-fed mice exhibited elevated SBP that was accompanied by an increase in the wall thickness and vascular cross-sectional area (P<0.05), 12 weeks post-HFD consumption. Treatment with THU (100 mg/kg/day) suppressed intrarenal RAS activation, improved insulin sensitivity, and reduced SBP, thus, attenuating kidney injury in these mice. Conclusion: THU alleviated kidney injury in mice with HFD-induced type 2 diabetes, possibly by blunting the activation of the in | - |
dc.format.extent | 13 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 대한내분비학회 | - |
dc.title | Tetrahydrocurcumin Ameliorates Kidney Injury and High Systolic Blood Pressure in High-Fat Diet-Induced Type 2 Diabetic Mice | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.3803/EnM.2021.988 | - |
dc.identifier.scopusid | 2-s2.0-85115191821 | - |
dc.identifier.wosid | 000692544000012 | - |
dc.identifier.bibliographicCitation | Endocrinology and Metabolism, v.36, no.4, pp 810 - 822 | - |
dc.citation.title | Endocrinology and Metabolism | - |
dc.citation.volume | 36 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 810 | - |
dc.citation.endPage | 822 | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002746958 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.subject.keywordPlus | ANGIOTENSIN SYSTEM | - |
dc.subject.keywordPlus | INSULIN-RESISTANCE | - |
dc.subject.keywordPlus | SIGNALING PATHWAYS | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | RENAL-DISEASE | - |
dc.subject.keywordPlus | OBESITY | - |
dc.subject.keywordPlus | HYPERTENSION | - |
dc.subject.keywordPlus | ANTIOXIDANT | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | BLOCKADE | - |
dc.subject.keywordAuthor | Diabetic nephropathies | - |
dc.subject.keywordAuthor | Renin-angiotensin system | - |
dc.subject.keywordAuthor | Hypertension | - |
dc.subject.keywordAuthor | Tetrahydrocurcumin | - |
dc.subject.keywordAuthor | Curcumin | - |
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