Clinical Outcome of Salvage Radiotherapy for Locoregional Clinical Recurrence After Radical Prostatectomy
DC Field | Value | Language |
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dc.contributor.author | Lee, Sung Uk | - |
dc.contributor.author | Cho, Kwan Ho | - |
dc.contributor.author | Kim, Jin Ho | - |
dc.contributor.author | Kim, Young Seok | - |
dc.contributor.author | Nam, Taek-Keun | - |
dc.contributor.author | Kim, Jae-Sung | - |
dc.contributor.author | Cho, Jaeho | - |
dc.contributor.author | Choi, Seo Hee | - |
dc.contributor.author | Shim, Su Jung | - |
dc.contributor.author | Kim, Jin Hee | - |
dc.contributor.author | Chang, Ah Ram | - |
dc.date.accessioned | 2021-12-07T07:40:38Z | - |
dc.date.available | 2021-12-07T07:40:38Z | - |
dc.date.issued | 2021-11 | - |
dc.identifier.issn | 1533-0346 | - |
dc.identifier.issn | 1533-0338 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/20061 | - |
dc.description.abstract | Objectives: To assess the clinical outcomes of prostate cancer patients treated with salvage radiotherapy (SRT) for locoregional clinical recurrence (CR) after radical prostatectomy (RP). Methods: Records of 60 patients with macroscopic locoregional recurrence after prostatectomy and referrals for SRT were retrospectively investigated in the multi-institutional database. The median radiation dose was 70.2 Gy. Biochemical failure was defined as the prostate-specific antigen (PSA) >= nadir + 2 or initiation of androgen deprivation therapy (ADT) for increased PSA. Results: Median recurrent tumor size was 1.1 cm and pre-radiotherapy PSA level was 0.4 ng/ml. At a median follow-up of 83.1-month after SRT, 7-year biochemical failure-free survival (BCFFS), locoregional failure-free survival (LRFFS), distant metastasis-free survival (DMFS), and overall survival (OS) were 67.0%, 89.7%, 83.6%, and 91.2%, respectively. Higher Gleason's scores were associated with unfavorable BCFFS, DMFS, and OS. Pre-SRT PSA >= 0.5 ng/ml predicted worse BCFFS, LRFFS, and DMFS. In multivariate analyses, a Gleason's score of 8 to 10 was associated with decreased BCFFS (hazard ratio [HR] 3.12, 95% confidence interval [CI] 1.11-8.74, P = .031) and OS (HR 17.72, 95% CI 1.75-179.64, P = .015), and combined ADT decreased the risks of distant metastasis (HR 0.18, 95% CI 0.04-0.92, P = .039). Two patients (3.3%) experienced late grade 3 urinary toxicity. Conclusions: SRT for locoregional CR after RP achieved favorable outcomes with acceptable long-term toxicities. Higher Gleason's scores and pre-radiotherapy PSA level were unfavorable prognostic variables. Combined ADT may decrease the risks of metastases. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Adenine Press | - |
dc.title | Clinical Outcome of Salvage Radiotherapy for Locoregional Clinical Recurrence After Radical Prostatectomy | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1177/15330338211041212 | - |
dc.identifier.scopusid | 2-s2.0-85124375449 | - |
dc.identifier.wosid | 000721612700001 | - |
dc.identifier.bibliographicCitation | Technology in Cancer Research and Treatment, v.20, no.0, pp 1 - 7 | - |
dc.citation.title | Technology in Cancer Research and Treatment | - |
dc.citation.volume | 20 | - |
dc.citation.number | 0 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 7 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.subject.keywordPlus | LYMPH-NODE DISSECTION | - |
dc.subject.keywordPlus | BIOCHEMICAL RECURRENCE | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | PROGRESSION | - |
dc.subject.keywordPlus | RADIATION | - |
dc.subject.keywordPlus | PET/CT | - |
dc.subject.keywordAuthor | prostatic neoplasms | - |
dc.subject.keywordAuthor | prostatectomy | - |
dc.subject.keywordAuthor | radiotherapy | - |
dc.subject.keywordAuthor | recurrence | - |
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