Practical Review of Biologics in Chronic Rhinosinusitis With Nasal Polypsopen accessPractical Review of Biologics in Chronic Rhinosinusitis With Nasal Polyps
- Other Titles
- Practical Review of Biologics in Chronic Rhinosinusitis With Nasal Polyps
- Authors
- 이기일; 류광희; 유신혁; 김용민; 모지훈; 신승헌
- Issue Date
- Nov-2021
- Publisher
- 대한비과학회
- Keywords
- Biologics; Sinusitis; Immunology; Nasal polyps; Interleukin-4 receptors
- Citation
- Journal of Rhinology, v.28, no.3, pp 131 - 140
- Pages
- 10
- Journal Title
- Journal of Rhinology
- Volume
- 28
- Number
- 3
- Start Page
- 131
- End Page
- 140
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/20087
- DOI
- 10.18787/jr.2021.00382
- ISSN
- 1229-1498
2384-4361
- Abstract
- Well-characterized in chronic rhinosinusitis, type 2 inflammation is frequently associated with nasal polyps, comorbid asthma, and nonsteroidal anti-inflammatory drug hypersensitivity. Despite medical and surgical treatment, it recurs in a significant proportion of patients. Thus, severe uncontrolled type 2 chronic rhinosinusitis with nasal polyps is the most difficult-to-treat phenotype of chronic rhinosinusitis. Recently, dupilumab, a monoclonal antibody against IL-4 receptor α, and omalizumab, a monoclonal antibody against immunoglobulin E, were approved for patients with chronic rhinosinusitis with nasal polyps in the United States, Europe, and Korea. Therefore, rhinologists should understand novel biologics and their use. Here, we provide a literature review of several biologics with their indications, effectiveness, and safety.
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