Exosomes isolated from melatonin-stimulated mesenchymal stem cells improve kidney function by regulating inflammation and fibrosis in a chronic kidney disease mouse model
DC Field | Value | Language |
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dc.contributor.author | Yea, Ji-Hye | - |
dc.contributor.author | Yoon, Yeo Min | - |
dc.contributor.author | Lee, Jun Hee | - |
dc.contributor.author | Yun, Chul Won | - |
dc.contributor.author | Lee, Sang Hun | - |
dc.date.accessioned | 2021-12-07T09:40:35Z | - |
dc.date.available | 2021-12-07T09:40:35Z | - |
dc.date.issued | 2021-11 | - |
dc.identifier.issn | 2041-7314 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/20101 | - |
dc.description.abstract | Chronic kidney disease (CKD) is defined as structural and functional abnormalities of the kidney due to inflammation and fibrosis. We investigated the therapeutic effects of exosomes secreted by melatonin-stimulated mesenchymal stem cells (Exocue) on the functional recovery of the kidney in a CKD mouse model. Exocue upregulated gene expression of micro RNAs (miRNAs) associated with anti-inflammatory and anti-fibrotic effects. Exocue-treated groups exhibited low tumor necrosis factor-alpha and transforming growth factor-beta levels in serum and fibrosis inhibition in kidney tissues mediated through regulation of cell apoptosis and proliferation of fibrosis-related cells. Exocue treatment decreased the gene expression of CKD progression-related miRNAs. Moreover, the CKD severity was alleviated in the Exocue group via upregulation of aquaporin 2 and 5 levels and reduction of blood urea nitrogen and creatinine, resulting in functional recovery of the kidney. In conclusion, Exocue could be a novel therapeutic agent for treating CKD by regulating inflammation and fibrosis. | - |
dc.format.extent | 13 | - |
dc.publisher | SAGE-Hindawi Access to Research | - |
dc.title | Exosomes isolated from melatonin-stimulated mesenchymal stem cells improve kidney function by regulating inflammation and fibrosis in a chronic kidney disease mouse model | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1177/20417314211059624 | - |
dc.identifier.scopusid | 2-s2.0-85120360928 | - |
dc.identifier.wosid | 000724531200001 | - |
dc.identifier.bibliographicCitation | Journal of Tissue Engineering, v.12, no.0, pp 1 - 13 | - |
dc.citation.title | Journal of Tissue Engineering | - |
dc.citation.volume | 12 | - |
dc.citation.number | 0 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 13 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Cell & Tissue Engineering | - |
dc.subject.keywordPlus | EXTRACELLULAR VESICLES | - |
dc.subject.keywordPlus | RENAL FIBROSIS | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | TARGETS | - |
dc.subject.keywordPlus | REPAIR | - |
dc.subject.keywordAuthor | Chronic kidney disease | - |
dc.subject.keywordAuthor | mesenchymal stem cell | - |
dc.subject.keywordAuthor | exosome | - |
dc.subject.keywordAuthor | inflammation | - |
dc.subject.keywordAuthor | fibrosis | - |
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