Decreased Cortical Thickness and Local Gyrification in Individuals with Subjective Cognitive Impairment
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Youn, HyunChul | - |
dc.contributor.author | Choi, Myungwon | - |
dc.contributor.author | Lee, Suji | - |
dc.contributor.author | Kim, Daegyeom | - |
dc.contributor.author | Suh, Sangil | - |
dc.contributor.author | Han, Cheol E. | - |
dc.contributor.author | Jeong, Hyun-Ghang | - |
dc.date.accessioned | 2021-12-08T09:40:31Z | - |
dc.date.available | 2021-12-08T09:40:31Z | - |
dc.date.issued | 2021-11 | - |
dc.identifier.issn | 1738-1088 | - |
dc.identifier.issn | 2093-4327 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/20118 | - |
dc.description.abstract | Objective: Subjective cognitive impairment (SCI) is associated with future cognitive decline. This study aimed to compare cortical thickness and local gyrification index (LGI) between individuals with SCI and normal control (NC) subjects. Methods: Forty-seven participants (27 SCI and 20 NC) were recruited. All participants underwent brain magnetic resonance imaging scanning and were clinically assessed using the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) battery of tests. We compared cortical thickness and LGI between the two groups and analyzed correlations between cortical thickness/LGI and scores on CERAD protocol subtests in the SCI group for region of interests with significant between-group differences. Results: Cortical thickness reduction in the left entorhinal, superior temporal, insular, rostral middle frontal, precentral, superior frontal, and supramarginal regions, and right supramarginal, precentral, insular, postcentral, and posterior cingulate regions was observed in the SCI compared to the NC group. Cortical thickness in these regions correlated with scores of constructional praxis, word list memory, word list recall, constructional recall, trail making test A, and verbal fluency under the CERAD protocol. Significantly decreased gyrification was observed in the left lingual gyrus of the SCI group. In addition, gyrification of this region was positively associated with scores of constructional praxis. Conclusion: Our results may provide an additional reference to the notion that SCI may be associated with future cognitive impairment. This study may help clinicians to assess individuals with SCI who may progress to mild cognitive impairment and Alzheimer's dementia. | - |
dc.format.extent | 13 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 대한정신약물학회 | - |
dc.title | Decreased Cortical Thickness and Local Gyrification in Individuals with Subjective Cognitive Impairment | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.9758/cpn.2021.19.4.640 | - |
dc.identifier.scopusid | 2-s2.0-85119604422 | - |
dc.identifier.wosid | 000712048500007 | - |
dc.identifier.bibliographicCitation | Clinical Psychopharmacology and Neuroscience, v.19, no.4, pp 640 - 652 | - |
dc.citation.title | Clinical Psychopharmacology and Neuroscience | - |
dc.citation.volume | 19 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 640 | - |
dc.citation.endPage | 652 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | VOXEL-BASED MORPHOMETRY | - |
dc.subject.keywordPlus | SURFACE-BASED ANALYSIS | - |
dc.subject.keywordPlus | MEMORY COMPLAINTS | - |
dc.subject.keywordPlus | ALZHEIMERS-DISEASE | - |
dc.subject.keywordPlus | NEUROPSYCHOLOGICAL ASSESSMENT | - |
dc.subject.keywordPlus | GLUCOSE-METABOLISM | - |
dc.subject.keywordPlus | FRONTAL GYRUS | - |
dc.subject.keywordPlus | AMYLOID-BETA | - |
dc.subject.keywordPlus | OLDER-ADULTS | - |
dc.subject.keywordPlus | CORTEX | - |
dc.subject.keywordAuthor | Alzheimer disease | - |
dc.subject.keywordAuthor | Cognitive decline | - |
dc.subject.keywordAuthor | Mild cognitive impairment | - |
dc.subject.keywordAuthor | Brain cortical thickness | - |
dc.subject.keywordAuthor | Local gyr-ification index | - |
dc.subject.keywordAuthor | Lingual gyrus | - |
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