EASL versus LI-RADS: Intra-individual comparison of MRI with extracellular contrast and gadoxetic acid for diagnosis of small HCC
DC Field | Value | Language |
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dc.contributor.author | Min, Ji Hye | - |
dc.contributor.author | Kim, Jong Man | - |
dc.contributor.author | Kim, Young Kon | - |
dc.contributor.author | Kim, Honsoul | - |
dc.contributor.author | Cha, Dong Ik | - |
dc.contributor.author | Kang, Tae Wook | - |
dc.contributor.author | Choi, Gyu Seong | - |
dc.contributor.author | Choi, Seo-Youn | - |
dc.contributor.author | Ahn, Soohyun | - |
dc.date.accessioned | 2022-01-25T01:40:29Z | - |
dc.date.available | 2022-01-25T01:40:29Z | - |
dc.date.issued | 2021-12 | - |
dc.identifier.issn | 1478-3223 | - |
dc.identifier.issn | 1478-3231 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/20268 | - |
dc.description.abstract | Background & Aims Liver Imaging Reporting and Data System (LI-RADS) and European Association for the Study (EASL) criteria for hepatocellular carcinoma (HCC) diagnosis have been updated in 2018. We aimed to compare the HCC diagnostic performance of LI-RADS and EASL criteria with extracellular contrast agents-MRI (ECA-MRI) and hepatobiliary agents-MRI (HBA-MRI). Methods We prospectively evaluated 179 participants with cirrhosis (n = 105) or non-cirrhotic chronic hepatitis B (CHB) (n = 74) who underwent both ECA-MRI and HBA-MRI before surgery for de novo nodule(s) measuring 10-30 mm. We compared the HCC diagnostic performance of EASL and LR-5 in both MRIs. Results In an analysis of 215 observations (175 HCCs, 17 non-HCC malignancies and 23 benign lesions) identified from cirrhotic or non-cirrhotic CHB participants, LR-5 with ECA-MRI provided the highest sensitivity (80.7%), followed by EASL with ECA-MRI (76.2%), LR-5 with HBA-MRI (67.3%) and EASL with HBA-MRI (63.0%, all P < .05). The specificities were comparable (89.4%-91.5%). When the analysis is limited to participants with pathological cirrhosis (123 observations), the sensitivity of LR-5 with ECA-MRI was similar to that of EASL with ECA-MRI (82.7% vs 80.2%, P = .156), but higher than LR-5 with HBA-MRI (65.1%) or EASL with HBA-MRI (62.8%, both P < .001), with comparable specificities (87.5%-91.7%). Conclusions The LR-5 with ECA-MRI yielded the highest sensitivity with a similar specificity for HCC diagnosis in cirrhosis and non-cirrhotic CHB participants, while the sensitivities of LR-5 and EASL with ECA-MRI are similar for cirrhosis participants. This indicates non-invasive diagnosis criteria can differ by contrast agents and presence of cirrhosis. | - |
dc.format.extent | 11 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Blackwell Publishing Inc. | - |
dc.title | EASL versus LI-RADS: Intra-individual comparison of MRI with extracellular contrast and gadoxetic acid for diagnosis of small HCC | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1111/liv.15012 | - |
dc.identifier.scopusid | 2-s2.0-85110729924 | - |
dc.identifier.wosid | 000674879300001 | - |
dc.identifier.bibliographicCitation | Liver International, v.41, no.12, pp 2986 - 2996 | - |
dc.citation.title | Liver International | - |
dc.citation.volume | 41 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 2986 | - |
dc.citation.endPage | 2996 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.subject.keywordPlus | HYPERVASCULAR HEPATOCELLULAR-CARCINOMA | - |
dc.subject.keywordPlus | GD-EOB-DTPA | - |
dc.subject.keywordPlus | NONINVASIVE DIAGNOSIS | - |
dc.subject.keywordPlus | DELAYED PHASES | - |
dc.subject.keywordPlus | LIVER | - |
dc.subject.keywordPlus | ACCURACY | - |
dc.subject.keywordPlus | CRITERIA | - |
dc.subject.keywordPlus | CT | - |
dc.subject.keywordPlus | PROGNOSIS | - |
dc.subject.keywordPlus | AGENTS | - |
dc.subject.keywordAuthor | contrast agent | - |
dc.subject.keywordAuthor | EASL | - |
dc.subject.keywordAuthor | hepatocellular carcinoma | - |
dc.subject.keywordAuthor | LI-RADS | - |
dc.subject.keywordAuthor | magnetic resonance imaging | - |
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