Anti-Tuberculosis Activity of Pediococcus acidilactici Isolated from Young Radish Kimchi against Mycobacterium tuberculosis
DC Field | Value | Language |
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dc.contributor.author | Yoon Youjin | - |
dc.contributor.author | Seo Hoonhee | - |
dc.contributor.author | Kim Sukyung | - |
dc.contributor.author | Lee Youngkyoung | - |
dc.contributor.author | Rahim MD Abdur | - |
dc.contributor.author | Lee Saebim | - |
dc.contributor.author | 송호연 | - |
dc.date.accessioned | 2022-03-10T01:40:57Z | - |
dc.date.available | 2022-03-10T01:40:57Z | - |
dc.date.issued | 2021-12 | - |
dc.identifier.issn | 1017-7825 | - |
dc.identifier.issn | 1738-8872 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/20517 | - |
dc.description.abstract | Tuberculosis is a highly contagious disease caused by Mycobacterium tuberculosis. It affects about 10 million people each year and is still one of the leading causes of death worldwide. About 2 to 3 billion people (equivalent to 1 in 3 people in the world) are infected with latent tuberculosis. Moreover, as the number of multidrug-resistant, extensively drug-resistant, and totally drug-resistant strains of M. tuberculosis continues to increase, there is an urgent need to develop new anti-tuberculosis drugs that are different from existing drugs to combat antibiotic-resistant M. tuberculosis. Against this background, we aimed to develop new anti-tuberculosis drugs using probiotics. Here, we report the anti-tuberculosis effect of Pediococcus acidilactici PMC202 isolated from young radish kimchi, a traditional Korean fermented food. Under coculture conditions, PMC202 inhibited the growth of M. tuberculosis. In addition, PMC202 inhibited the growth of drug-sensitive and -resistant M. tuberculosis- infected macrophages at a concentration that did not show cytotoxicity and showed a synergistic effect with isoniazid. In a 2-week, repeated oral administration toxicity study using mice, PMC202 did not cause weight change or specific clinical symptoms. Furthermore, the results of 16S rRNA-based metagenomics analysis confirmed that dysbiosis was not induced in bronchoalveolar lavage fluid after oral administration of PMC202. The anti-tuberculosis effect of PMC202 was found to be related to the reduction of nitric oxide. Our findings indicate that PMC202 could be used as an anti-tuberculosis drug candidate with the potential to replace current chemicalbased drugs. However, more extensive toxicity, mechanism of action, and animal efficacy studies with clinical trials are needed. | - |
dc.format.extent | 11 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 한국미생물·생명공학회 | - |
dc.title | Anti-Tuberculosis Activity of Pediococcus acidilactici Isolated from Young Radish Kimchi against Mycobacterium tuberculosis | - |
dc.title.alternative | Anti-Tuberculosis Activity of Pediococcus acidilactici Isolated from Young Radish Kimchi against Mycobacterium tuberculosis | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.4014/jmb.2107.07044 | - |
dc.identifier.scopusid | 2-s2.0-85122973173 | - |
dc.identifier.wosid | 000738858900004 | - |
dc.identifier.bibliographicCitation | Journal of Microbiology and Biotechnology, v.31, no.12, pp 1632 - 1642 | - |
dc.citation.title | Journal of Microbiology and Biotechnology | - |
dc.citation.volume | 31 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 1632 | - |
dc.citation.endPage | 1642 | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002787951 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalResearchArea | Microbiology | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Microbiology | - |
dc.subject.keywordPlus | NITRIC-OXIDE | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | PROBIOTICS | - |
dc.subject.keywordPlus | MICROBIOME | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | PREVENTION | - |
dc.subject.keywordPlus | MANAGEMENT | - |
dc.subject.keywordAuthor | Mycobacterium tuberculosis | - |
dc.subject.keywordAuthor | Pediococcus acidilactici | - |
dc.subject.keywordAuthor | probiotics | - |
dc.subject.keywordAuthor | anti-tuberculosis effect | - |
dc.subject.keywordAuthor | microbiome | - |
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