Enantioselective one-pot synthesis of 2-amino-4H-chromenes via C-H oxidation and Michael addition/ring closure sequences

Abstract

The chiral 2-amino-4H-chromene derivatives were obtained from 2-alkyl-substituted phenol derivatives in moderate to high yields with excellent enantioselectivities through one-pot cascade via C-H oxidation/Michael addition/ring closure sequences using a binaphthyl-modified organocatalyst with low catalyst loading (1.25 mol%).