Sex, menopause, and age differences in the associations of persistent organic pollutants with thyroid hormones, thyroxine-binding globulin, and peripheral deiodinase activity: A cross-sectional study of the general Korean adult population
DC Field | Value | Language |
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dc.contributor.author | Kim, Min Joo | - |
dc.contributor.author | Choi, Sohyeon | - |
dc.contributor.author | Kim, Sunmi | - |
dc.contributor.author | Lee, Inae | - |
dc.contributor.author | Moon, Min Kyong | - |
dc.contributor.author | Choi, Kyungho | - |
dc.contributor.author | Park, Jeongim | - |
dc.contributor.author | Cho, Yoon Hee | - |
dc.contributor.author | Kwon, Young Min | - |
dc.contributor.author | Yoo, Jiyoung | - |
dc.contributor.author | Cheon, Gi Jeong | - |
dc.contributor.author | Park, Young Joo | - |
dc.date.accessioned | 2022-04-14T04:40:12Z | - |
dc.date.available | 2022-04-14T04:40:12Z | - |
dc.date.issued | 2022-09 | - |
dc.identifier.issn | 0013-9351 | - |
dc.identifier.issn | 1096-0953 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/20624 | - |
dc.description.abstract | Persistent organic pollutants (POPs) can disrupt the thyroid hormone system in humans. We assessed the associations of several POPs with serum thyroid hormones (T3 and T4) and thyroid-stimulating hormone, and investigated the modulating effects of sex, menopausal status, and age on these associations, in a subgroup of the adult population (n = 1250) from the Korean National Environmental Health Survey. PCB105 and PCB118 were negatively associated with total T4 in premenopausal females and males aged < 50, whereas the associations were insignificant in other groups. PCB180, p,p'-DDE, and p,p'-DDT showed positive associations with total T3 in postmenopausal females; however, among males aged > 50, PCB118, PCB138, and p,p'-DDE showed negative associations with total T3. The effects of exposure to multiple POPs were examined in multi-factor analyses. Factor 2 comprised PCB52, hexachlorobenzene, and BDE-47 was associated with an increase in free T4 in premenopausal females (beta = 0.015, p = 0.024), while Factor 1, which contained most POPs, was associated with a change in total T3 in postmenopausal females (beta = 0.032, p = 0.040) and males aged >= 50 (beta =-0.039, p = 0.023). Changes in total T4 or total T3 could be explained by differences in thyroxine-binding globulin (TBG) and peripheral deiodinase activity (G(D)). Negative associations of TBG with PCB105 in premenopausal females and PCB153 in males aged < 50 may mediate the effect of decreasing total T4. PCB180, p,p'-DDE, p,p'-DDT, and Factor 1 were positively associated with G(D), which is consistent with an increased total T3 in postmenopausal females. PCB118 was negatively associated with G(D) and total T3 in males aged >= 50. BDE-47 and beta-hexa-chlorocyclohexane were associated with thyroid autoantibodies in premenopausal females and males aged < 50. Our observations suggest that the thyroid-disrupting effects of POPs may differ by sex, sex hormonal status, and age, and may be mediated by TBG and G(D). | - |
dc.format.extent | 10 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Academic Press | - |
dc.title | Sex, menopause, and age differences in the associations of persistent organic pollutants with thyroid hormones, thyroxine-binding globulin, and peripheral deiodinase activity: A cross-sectional study of the general Korean adult population | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1016/j.envres.2022.113143 | - |
dc.identifier.scopusid | 2-s2.0-85127459969 | - |
dc.identifier.wosid | 000793114600001 | - |
dc.identifier.bibliographicCitation | Environmental Research, v.212, no.A, pp 1 - 10 | - |
dc.citation.title | Environmental Research | - |
dc.citation.volume | 212 | - |
dc.citation.number | A | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 10 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Environmental Sciences & Ecology | - |
dc.relation.journalResearchArea | Public, Environmental & Occupational Health | - |
dc.relation.journalWebOfScienceCategory | Environmental Sciences | - |
dc.relation.journalWebOfScienceCategory | Public, Environmental & Occupational Health | - |
dc.subject.keywordPlus | POLYCHLORINATED-BIPHENYLS | - |
dc.subject.keywordPlus | ENVIRONMENTAL CHEMICALS | - |
dc.subject.keywordPlus | SERUM CONCENTRATIONS | - |
dc.subject.keywordPlus | EXPOSURE | - |
dc.subject.keywordPlus | ORGANOCHLORINES | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordAuthor | Iodothyronine deiodinase | - |
dc.subject.keywordAuthor | Persistent organic pollutants | - |
dc.subject.keywordAuthor | Polychlorinated biphenyls | - |
dc.subject.keywordAuthor | Thyroid stimulating hormone (TSH) | - |
dc.subject.keywordAuthor | Thyroid hormones | - |
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