Bone formation effect of highly concentrated tricalcium phosphate biocomposite screws in a rabbit osteoporosis model
DC Field | Value | Language |
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dc.contributor.author | Jeong, Je Hoon | - |
dc.contributor.author | Jin, Eun-Sun | - |
dc.contributor.author | Kim, Ji Yeon | - |
dc.contributor.author | Min, JoongKee | - |
dc.contributor.author | Jeon, Sang Ryong | - |
dc.contributor.author | Lee, Minsu | - |
dc.contributor.author | Choi, Kyoung Hyo | - |
dc.date.accessioned | 2022-05-24T02:49:44Z | - |
dc.date.available | 2022-05-24T02:49:44Z | - |
dc.date.issued | 2022-06 | - |
dc.identifier.issn | 0736-0266 | - |
dc.identifier.issn | 1554-527X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/20778 | - |
dc.description.abstract | The purpose of this study was to determine the efficacy of highly concentrated tricalcium phosphate (TCP) biocomposite screws on local bone formation in a rabbit model of osteoporosis induced by bilateral ovariohysterectomy (OHE). Fourteen 24-week-old female New Zealand rabbits (weight, 3-3.5 kg) were divided into two groups: (1) OHE and biodegradable poly(lactic-co-glycolic acid) (PLGA) without ss-TCP plate or screw insertion (OHE/Bio ScRew [BSR]) group and (2) OHE and biocomposite PLGA with highly concentrated ss-TCP plate and screw insertion (OHE/highly concentrated ss-triCalcium phosphate [HCCP]). Both groups underwent bilateral OHE and had two different types of screws and plates inserted at the proximal tibia. Bilateral tibiae were extracted at 25 weeks post-OHE. The extracted tibiae were scanned with ex vivo microcomputed tomography (micro-CT). Parameters including bone mineral density (BMD), trabecular bone volume (BV/TV), trabecular number (Tb.N), trabecular thickness (Tb. Th), and trabecular separation (Tb. Sp) were evaluated after staining the tibial samples with hematoxylin and eosin (H&E) and Masson's trichrome. We then performed pathological assessments. Micro-CT images revealed improved new bone formation near the implant in the OHE/HCCP group with higher values of BMD, BV/TV, and Tb.N but lower values of Tb. Th and Tb. Sp than the OHE/BSR group. Analyses of H&E and Masson's trichrome staining showed better new bone formation around the implant in the OHE/HCCP group than in the OHE/BSR group. The use of highly concentrated TCP biocomposite screw and plate might improve local bone formation and facilitate osteoconductivity in an osteoporotic rabbit model. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Elsevier BV | - |
dc.title | Bone formation effect of highly concentrated tricalcium phosphate biocomposite screws in a rabbit osteoporosis model | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1002/jor.25171 | - |
dc.identifier.scopusid | 2-s2.0-85114842857 | - |
dc.identifier.wosid | 000695917800001 | - |
dc.identifier.bibliographicCitation | Journal of Orthopaedic Research, v.40, no.6, pp 1321 - 1328 | - |
dc.citation.title | Journal of Orthopaedic Research | - |
dc.citation.volume | 40 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1321 | - |
dc.citation.endPage | 1328 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Orthopedics | - |
dc.relation.journalWebOfScienceCategory | Orthopedics | - |
dc.subject.keywordPlus | CRUCIATE LIGAMENT RECONSTRUCTION | - |
dc.subject.keywordPlus | L-LACTIC ACID | - |
dc.subject.keywordPlus | INTERFERENCE SCREWS | - |
dc.subject.keywordPlus | GRAFT FIXATION | - |
dc.subject.keywordPlus | COMPOSITE | - |
dc.subject.keywordPlus | BIOCOMPATIBILITY | - |
dc.subject.keywordPlus | DEGRADATION | - |
dc.subject.keywordPlus | CEMENT | - |
dc.subject.keywordAuthor | animal model | - |
dc.subject.keywordAuthor | biocomposite screw | - |
dc.subject.keywordAuthor | implant | - |
dc.subject.keywordAuthor | osteoporosis | - |
dc.subject.keywordAuthor | tricalcium phosphate | - |
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