Young adults with nonalcoholic fatty liver disease, defined using the fatty liver index, can be at increased risk of myocardial infarction or stroke
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chung, Goh Eun | - |
dc.contributor.author | Cho, Eun Ju | - |
dc.contributor.author | Yoo, Jeong-Ju | - |
dc.contributor.author | Chang, Young | - |
dc.contributor.author | Cho, Yuri | - |
dc.contributor.author | Park, Sang-Hyun | - |
dc.contributor.author | Han, Kyungdo | - |
dc.contributor.author | Jeong, Su-Min | - |
dc.contributor.author | Yoon, Kyoung Wan | - |
dc.contributor.author | Shin, Dong Wook | - |
dc.contributor.author | Yu, Su Jong | - |
dc.contributor.author | Kim, Yoon Jun | - |
dc.contributor.author | Yoon, Jung-Hwan | - |
dc.date.accessioned | 2022-05-24T02:49:54Z | - |
dc.date.available | 2022-05-24T02:49:54Z | - |
dc.date.issued | 2022-03 | - |
dc.identifier.issn | 1462-8902 | - |
dc.identifier.issn | 1463-1326 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/20782 | - |
dc.description.abstract | Aim To investigate the relationship between nonalcoholic fatty liver disease (NAFLD) and cardiovascular events among a nationally representative sample of young adults in Korea. Methods and Results This population-based cohort study from the Korean National Health Insurance Service included adults who were aged 20 to 39 years when they underwent a health examination between 2009 and 2012. NAFLD was defined as a fatty liver index (FLI) >= 60, and participants were divided into three groups according to FLI (<30, 30-59 and >= 60) to investigate the dose-dependent effect of FLI score. Among 5 324 410 participants, 9.8% had an FLI >= 60. There were 13 051 myocardial infarctions (MIs; 0.39%) and 8573 strokes (0.26%) during a median follow-up of 8.4 years. In multivariable analysis, NAFLD was associated with a higher risk of MI and stroke (hazard ratio [HR] 1.69, 95% confidence interval [CI] 1.61-1.77 and HR 1.73, 95% CI 1.63-1.84, respectively). MI and stroke had dose-dependent relationships with FLI (HR 1.28 in participants with FLI 30-59 and 1.73 in those with FLI >= 60 for MI and HR 1.18 in participants with FLI 30-59 and 1.41 in those with FLI >= 60 for stroke, respectively). Conclusions Nonalcholic fatty liver disease was an independent predictor of MI and stroke in young adults. These results suggest that primary prevention of cardiovascular disease should be emphasized in young adults with NAFLD. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Blackwell Publishing Inc. | - |
dc.title | Young adults with nonalcoholic fatty liver disease, defined using the fatty liver index, can be at increased risk of myocardial infarction or stroke | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1111/dom.14597 | - |
dc.identifier.scopusid | 2-s2.0-85120379477 | - |
dc.identifier.wosid | 000724568400001 | - |
dc.identifier.bibliographicCitation | Diabetes, Obesity and Metabolism, v.24, no.3, pp 465 - 472 | - |
dc.citation.title | Diabetes, Obesity and Metabolism | - |
dc.citation.volume | 24 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 465 | - |
dc.citation.endPage | 472 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.subject.keywordPlus | AMERICAN-COLLEGE | - |
dc.subject.keywordPlus | MORTALITY | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | VALIDATION | - |
dc.subject.keywordPlus | GUIDELINE | - |
dc.subject.keywordPlus | AGE | - |
dc.subject.keywordAuthor | myocardial infarction | - |
dc.subject.keywordAuthor | risk | - |
dc.subject.keywordAuthor | steatosis | - |
dc.subject.keywordAuthor | stroke | - |
dc.subject.keywordAuthor | young adult | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(31538) 22, Soonchunhyang-ro, Asan-si, Chungcheongnam-do, Republic of Korea+82-41-530-1114
COPYRIGHT 2021 by SOONCHUNHYANG UNIVERSITY ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.