Transiently Observed Trace Albuminuria on Urine Dipstick Test Is Associated With All-Cause Death, Cardiovascular Death, and Incident Chronic Kidney Disease: A National Health Insurance Service-National Sample Cohort in Korea
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Samel | - |
dc.contributor.author | Woo, Jiyoung | - |
dc.contributor.author | Leem, Subeen | - |
dc.contributor.author | Heo, Nam Hun | - |
dc.contributor.author | Cho, Nam-Jun | - |
dc.contributor.author | Gil, Hyowook | - |
dc.contributor.author | Kim, Jae Heon | - |
dc.contributor.author | Lee, Eun Young | - |
dc.date.accessioned | 2022-05-27T07:40:04Z | - |
dc.date.available | 2022-05-27T07:40:04Z | - |
dc.date.issued | 2022-05 | - |
dc.identifier.issn | 2297-055X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/20825 | - |
dc.description.abstract | IntroductionAlbuminuria is a well-known risk factor for end-stage kidney disease, all-cause mortality, and cardiovascular mortality, even when the albumin-to-creatinine ratio is <30 mg/g. However, the association between transiently observed trace albuminuria and these major adverse outcomes has not yet been reported. This study aimed to examine the effect of transient albuminuria on these major adverse outcomes using the National Health Insurance Service data in Korea. Methods and ResultsThe National Health Insurance Service-National Sample Cohort from Korea, followed from 2002 to 2015, consisted of 1,025,340 individuals, accounting for 2.2% of the total Korean population. We analyzed the effect of transient albuminuria on all-cause death, cardiovascular death, and incident chronic kidney disease (CKD) and compared it with the group without albuminuria. Among 1,025,340 individuals, 121,876 and 2,815 had transient albuminuria and no albuminuria, respectively. Adjusted hazard ratios of the transient albuminuria group for cardiovascular death and incident CKD were 1.76 (1.01-3.08) and 1.28 (1.15-1.43), respectively. There were significant differences in all-cause death, cardiovascular death, and incident CKD between the two groups after propensity score matching (p = 0.0037, p = 0.015, and p < 0.0001, respectively). Propensity score matching with bootstrapping showed that the hazard ratios of the transient albuminuria group for all-cause death and cardiovascular death were 1.39 (1.01-1.92) and 2.18 (1.08-5.98), respectively. ConclusionsIn this nationwide, large-scale, retrospective cohort study, transient albuminuria was associated with all-cause death, cardiovascular death, and incident CKD, suggesting that transient albuminuria could be a risk marker for adverse outcomes in the future, and that its own subclinical phenotype could play an important role during the course of CKD. | - |
dc.format.extent | 10 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Frontiers Media S.A. | - |
dc.title | Transiently Observed Trace Albuminuria on Urine Dipstick Test Is Associated With All-Cause Death, Cardiovascular Death, and Incident Chronic Kidney Disease: A National Health Insurance Service-National Sample Cohort in Korea | - |
dc.type | Article | - |
dc.publisher.location | 스위스 | - |
dc.identifier.doi | 10.3389/fcvm.2022.882599 | - |
dc.identifier.scopusid | 2-s2.0-85138867152 | - |
dc.identifier.wosid | 000796569400001 | - |
dc.identifier.bibliographicCitation | Frontiers in Cardiovascular Medicine, v.9, no.0, pp 1 - 10 | - |
dc.citation.title | Frontiers in Cardiovascular Medicine | - |
dc.citation.volume | 9 | - |
dc.citation.number | 0 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 10 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cardiovascular System & Cardiology | - |
dc.relation.journalWebOfScienceCategory | Cardiac & Cardiovascular Systems | - |
dc.subject.keywordPlus | LOW-GRADE ALBUMINURIA | - |
dc.subject.keywordPlus | GLOMERULAR-FILTRATION-RATE | - |
dc.subject.keywordPlus | PROPENSITY SCORE METHODS | - |
dc.subject.keywordPlus | COLLABORATIVE METAANALYSIS | - |
dc.subject.keywordPlus | SUBSEQUENT RISK | - |
dc.subject.keywordPlus | PROTEINURIA | - |
dc.subject.keywordPlus | MORTALITY | - |
dc.subject.keywordPlus | OUTCOMES | - |
dc.subject.keywordPlus | ADULTS | - |
dc.subject.keywordPlus | TIME | - |
dc.subject.keywordAuthor | albuminuria | - |
dc.subject.keywordAuthor | low-grade albuminuria | - |
dc.subject.keywordAuthor | cardiovascular mortality | - |
dc.subject.keywordAuthor | all-cause mortality | - |
dc.subject.keywordAuthor | chronic kidney disease | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(31538) 22, Soonchunhyang-ro, Asan-si, Chungcheongnam-do, Republic of Korea+82-41-530-1114
COPYRIGHT 2021 by SOONCHUNHYANG UNIVERSITY ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.