Fluorescent and Iodized Emulsion for Preoperative Localization of Pulmonary Nodules
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Rho, Jiyun | - |
dc.contributor.author | Lee, Jae Wook | - |
dc.contributor.author | Quan, Yu Hua | - |
dc.contributor.author | Choi, Byeong Hyeon | - |
dc.contributor.author | Shin, Bong Kyung | - |
dc.contributor.author | Han, Kook Nam | - |
dc.contributor.author | Kim, Beop-Min | - |
dc.contributor.author | Choi, Young Ho | - |
dc.contributor.author | Yong, Hwan Seok | - |
dc.contributor.author | Kim, Hyun Koo | - |
dc.date.accessioned | 2022-06-03T01:40:08Z | - |
dc.date.available | 2022-06-03T01:40:08Z | - |
dc.date.issued | 2021-05 | - |
dc.identifier.issn | 0003-4932 | - |
dc.identifier.issn | 1528-1140 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/20913 | - |
dc.description.abstract | Objective: This study was conducted to develop a fluorescent iodized emulsion comprising indocyanine green (ICG) solution and lipiodol (ethiodized oil) and evaluate its feasibility for use in a clinical setting. Background: ICG use for the preoperative localization of pulmonary nodules is limited in terms of penetration depth and diffusion. Methods: First, fluorescent microscopy was used to investigate the distribution of ICG-lipiodol emulsions prepared using different methods. The emulsions were injected in 15 lung lobes of 3 rabbits under computed tomography fluoroscopy guidance; evaluation with imaging and radiography was conducted after thoracotomy. Subsequently, the emulsions were used to preoperatively localize 29 pulmonary nodules in 24 human subjects, and wedge resections were performed using fluorescent imaging and C-arm fluoroscopy. Results: The optimal emulsion of 10% ICG and 90% lipiodol mixed through 90 passages had even distribution and the highest signal intensity under fluorescent microscopy; it also had the best consistency in the rabbit lungs, which persisted for 24 hours at the injection site. In human subjects, the mean diameter of pulmonary nodules was 0.9 +/- 0.4 cm, and depth from the pleura was 1.2 +/- 0.8 cm. All emulsion types injected were well localized around the target nodules without any side effects or procedure-related complications. Wedge resection with minimally invasive approach was successful in all pulmonary nodules with a free resection margin. Conclusions: A fluorescent iodized emulsion prepared by mixing ICG with lipiodol enabled accurate localization and resection of pulmonary nodules. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | J. B. Lippincott Company | - |
dc.title | Fluorescent and Iodized Emulsion for Preoperative Localization of Pulmonary Nodules | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1097/SLA.0000000000003300 | - |
dc.identifier.scopusid | 2-s2.0-85104046738 | - |
dc.identifier.wosid | 000662180400035 | - |
dc.identifier.bibliographicCitation | Annals of Surgery, v.273, no.5, pp 989 - 996 | - |
dc.citation.title | Annals of Surgery | - |
dc.citation.volume | 273 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 989 | - |
dc.citation.endPage | 996 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Surgery | - |
dc.relation.journalWebOfScienceCategory | Surgery | - |
dc.subject.keywordPlus | NEAR-INFRARED FLUORESCENCE | - |
dc.subject.keywordPlus | ASSISTED THORACOSCOPIC SURGERY | - |
dc.subject.keywordPlus | INDOCYANINE GREEN | - |
dc.subject.keywordPlus | METHYLENE-BLUE | - |
dc.subject.keywordPlus | LUNG-CANCER | - |
dc.subject.keywordPlus | RESECTION | - |
dc.subject.keywordPlus | LIPIODOL | - |
dc.subject.keywordPlus | INJECTION | - |
dc.subject.keywordPlus | MARKING | - |
dc.subject.keywordPlus | MIXTURE | - |
dc.subject.keywordAuthor | indocyanine green | - |
dc.subject.keywordAuthor | lipiodol | - |
dc.subject.keywordAuthor | localization | - |
dc.subject.keywordAuthor | pulmonary nodule | - |
dc.subject.keywordAuthor | wedge resection | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(31538) 22, Soonchunhyang-ro, Asan-si, Chungcheongnam-do, Republic of Korea+82-41-530-1114
COPYRIGHT 2021 by SOONCHUNHYANG UNIVERSITY ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.