Triglyceride glucose index is superior biomarker for predicting type 2 diabetes mellitus in children and adolescents
DC Field | Value | Language |
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dc.contributor.author | Yoon, Jong Seo | - |
dc.contributor.author | Lee, Hye Jin | - |
dc.contributor.author | Jeong, Hwal Rim | - |
dc.contributor.author | Shim, Young Suk | - |
dc.contributor.author | Kang, Min Jae | - |
dc.contributor.author | Hwang, Il Tae | - |
dc.date.accessioned | 2022-06-14T02:50:24Z | - |
dc.date.available | 2022-06-14T02:50:24Z | - |
dc.date.issued | 2022-05 | - |
dc.identifier.issn | 0918-8959 | - |
dc.identifier.issn | 1348-4540 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/21048 | - |
dc.description.abstract | The triglyceride-glucose (TyG) index is associated with predicting type 2 diabetes mellitus (T2DM), but its relationship with homeostatic model assessment of insulin resistance (HOMA-IR) in T2DM is not established. We aimed to investigate the role of TyG index for detection of T2DM in children and adolescents and compare it with HOMA-IR. A cross sectional study was performed in 176 overweight or obese children and adolescents with mean age of 11.34 +/- 3.24 years. TyG index was calculated as ln (fasting triglyceride (TG) [mg/dL] x fasting glucose [mg/dL]/2). Of a total of 176 subjects, 57 (32%) were diagnosed with T2DM. Significant differences were observed in the TyG index between T2DM and non-T2DM (p < 0.001). The TyG index had a positive correlation with fasting glucose (r = 0.519, p < 0.001), HOMA-IR (r = 0.189, p < 0.017), HbA1c (r = 0.429, p < 0.001), total cholesterol (TC) (r = 0.257, p = 0.001), TG (r = 0.759, p < 0.001), and low density lipoprotein cholesterol (LDL-C)(r = 0.152, p < 0.001), and a negative correlation with high-density lipoprotein cholesterol (HDL-C)(r = -0.107, p < 0.001) after controlling for sex, age and BMI standard deviation scores (SDS). In multiple regression analyses, 91.8% of the variance in TyG index was explained by age, glucose, HOMA-IR, TG, LDL-C, and HDL-C (p < 0.001). In the receiver operating characteristic (ROC) analysis, the TyG index [area under the curve (AUC) 0.839)] showed a better performance compared to HOMA-IR (AUC 0.645) in identifying patients with T2DM (p < 0.001). In conclusion, the TyG index had significant association with insulin resistance in T2DM and was superior to HOMA-IR in predicting T2DM in children and adolescents. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Japan Endocrine Sociey/Nihon Naibunpi Gakkai | - |
dc.title | Triglyceride glucose index is superior biomarker for predicting type 2 diabetes mellitus in children and adolescents | - |
dc.type | Article | - |
dc.publisher.location | 일본 | - |
dc.identifier.doi | 10.1507/endocrj.EJ21-0560 | - |
dc.identifier.scopusid | 2-s2.0-85131269158 | - |
dc.identifier.wosid | 000736193800001 | - |
dc.identifier.bibliographicCitation | Endocrine Journal, v.69, no.5, pp 559 - 565 | - |
dc.citation.title | Endocrine Journal | - |
dc.citation.volume | 69 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 559 | - |
dc.citation.endPage | 565 | - |
dc.type.docType | Article; Early Access | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.subject.keywordPlus | HOMEOSTASIS MODEL ASSESSMENT | - |
dc.subject.keywordPlus | INSULIN-RESISTANCE | - |
dc.subject.keywordPlus | TYG INDEX | - |
dc.subject.keywordPlus | HOMA-IR | - |
dc.subject.keywordPlus | SURROGATE | - |
dc.subject.keywordPlus | PLASMA | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordAuthor | Key words | - |
dc.subject.keywordAuthor | Triglyceride glucose index | - |
dc.subject.keywordAuthor | Insulin resistance | - |
dc.subject.keywordAuthor | Type 2 diabetes mellitus | - |
dc.subject.keywordAuthor | Surrogate marker | - |
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