Exosomal miRNA Profile in Small-for-Gestational-Age Children: A Potential Biomarker for Catch-Up Growth
DC Field | Value | Language |
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dc.contributor.author | Jeong, Hwal Rim | - |
dc.contributor.author | Han, Jae-A | - |
dc.contributor.author | Kim, Heeji | - |
dc.contributor.author | Lee, Hye Jin | - |
dc.contributor.author | Shim, Young Suk | - |
dc.contributor.author | Kang, Min Jae | - |
dc.contributor.author | Yoon, Jong Seo | - |
dc.contributor.author | Ryu, Seongho | - |
dc.contributor.author | Hwang, Il Tae | - |
dc.date.accessioned | 2022-07-05T01:40:19Z | - |
dc.date.available | 2022-07-05T01:40:19Z | - |
dc.date.issued | 2022-06 | - |
dc.identifier.issn | 2073-4425 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/21130 | - |
dc.description.abstract | Objective: The mechanism underlying postnatal growth failure and catch-up growth in small-for-gestational-age (SGA) children is poorly understood. This study investigated the exosomal miRNA signature associated with catch-up growth in SGA children. Methods: In total, 16 SGA and 10 appropriate-for-gestational-age (AGA) children were included. Serum exosomal miRNA was analyzed using next-generation sequencing (NGS). Exosomal miRNA was profiled for five SGA children with catch-up growth (SGA-CU), six SGA children without CU growth (SGA-nCU), and five AGA children. Results: Exosomal miRNA profiles were clustered into three clear groups. The exosomal miRNA expression profiles of the SGA-nCU group differed from those of the SGA-CU and AGA groups. In all, 22 miRNAs were differentially expressed between SGA-nCU and AGA, 19 between SGA-nCU and SGA-CU, and only 6 between SGA-CU and AGA. In both SGA-nCU and SGA-CU, miR-874-3p was upregulated and miR-6126 was downregulated. Therefore, these two miRNAs could serve as biomarkers for SGA. Compared with SGA-CU and AGA, miR-30c-5p, miR-363-3p, miR-29a-3p, and miR-29c-3p were upregulated in SGA-nCU, while miR-629-5p and miR-23a-5p were downregulated. These six miRNAs could be associated with growth failure in SGA-nCU children. Conclusions: SGA children without CU have a distinct exosomal miRNA expression profile compared with AGA and SGA children with CU. Exosomal miRNAs could serve as novel biomarkers for CU. | - |
dc.format.extent | 15 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | - |
dc.title | Exosomal miRNA Profile in Small-for-Gestational-Age Children: A Potential Biomarker for Catch-Up Growth | - |
dc.type | Article | - |
dc.publisher.location | 스위스 | - |
dc.identifier.doi | 10.3390/genes13060938 | - |
dc.identifier.scopusid | 2-s2.0-85131362565 | - |
dc.identifier.wosid | 000816153900001 | - |
dc.identifier.bibliographicCitation | Genes, v.13, no.6, pp 1 - 15 | - |
dc.citation.title | Genes | - |
dc.citation.volume | 13 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 15 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Genetics & Heredity | - |
dc.relation.journalWebOfScienceCategory | Genetics & Heredity | - |
dc.subject.keywordPlus | FULL-TERM | - |
dc.subject.keywordPlus | FACTOR-I | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | MIR-23A-5P | - |
dc.subject.keywordPlus | MANAGEMENT | - |
dc.subject.keywordPlus | STATEMENT | - |
dc.subject.keywordPlus | DIAGNOSIS | - |
dc.subject.keywordPlus | INFANTS | - |
dc.subject.keywordPlus | SERUM | - |
dc.subject.keywordPlus | BIRTH | - |
dc.subject.keywordAuthor | SGA | - |
dc.subject.keywordAuthor | catch-up growth | - |
dc.subject.keywordAuthor | miRNA | - |
dc.subject.keywordAuthor | exosome | - |
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